12-363 | PRAK Substrate Peptide

12-363
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue Number12-363
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPRAK Substrate Peptide
      References
      Product Information
      PresentationLyophilized powder
      Applications
      ApplicationPRAK Substrate Peptide primarily used in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
      Gene Symbol
      • MAPKAPK5
      • PRAK
      Protein TargetPRAK
      Target Sub-FamilyCAMK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8IW41 # Mediates stress-induced small heat shock protein 27 phosphorylation.
      SIZE: 473 amino acids; 54220 Da
      SUBUNIT: Interacts with SQSTM1.
      SUBCELLULAR LOCATION: Cytoplasm (Probable). Nucleus. Note=Also observed in the nucleus.
      TISSUE SPECIFICITY: Expressed ubiquitously.
      PTM: Phosphorylated on Thr-182; which is the regulatory phosphorylation site and is located on the T-loop/loop 12.
      SIMILARITY: SwissProt: Q8IW41 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by by Protein Kinase Assay by using PRAK (14-334) to phosphorylate PRAK substrate peptide.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsLyophilized: 2 years at 4°C; Rehydrated: 6 months at -20°C.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      PRAK Substrate Peptide - 18727 18727
      PRAK Substrate Peptide - 1987675 1987675
      PRAK Substrate Peptide - 22602 22602
      PRAK Substrate Peptide - 23304 23304
      PRAK Substrate Peptide - 23304A 23304A
      PRAK Substrate Peptide - 27531 27531
      PRAK Substrate Peptide - DAM1653156 DAM1653156
      PRAK Substrate Peptide - DAM1823407 DAM1823407

      References

      Reference overviewPub Med ID
      PRAK, a novel protein kinase regulated by the p38 MAP kinase.
      New, L, et al.
      EMBO J., 17: 3372-84 (1998)  1998

      Show Abstract
      9628874 9628874

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates