525331 | Photochromic Ion Channel Blocker, QAQ - Calbiochem

525331
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      525331-10MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 10 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA membrane-impermeant Na+, K+, and Ca2+ channel blocker that is structurally composed of two azo-linked QX-314 (Cat. No. 552234) type quaternary amines. Both QX-314 and QAQ are shown to selectively target excitability of nociceptor neurons via TRPV1-dependent cellular uptake. Unlike QX-314, the channel blocking activity of QAQ can be quickly switched on and off via optical cis-to-trans (500 nm) and trans-to-cis (320 nm) isomerization. Its efficacy as a pain-selective, photochromic anesthetic has been demonstrated in rats in vivo. QAQ cellular uptake can also be achieved by ATP-activated P2X7 receptor.
          Catalogue Number525331
          Brand Family Calbiochem®
          Synonyms2,2'-((diazene-1,2-diylbis(4,1-phenylene))bis(azanediyl))bis(N,N,N-triethyl-2-oxoethanaminium) formate, Quaternary Ammonium–Azobenzene–Quaternary Ammonium
          References
          ReferencesMourot, A., et al. 2012. Nat Methods. 9, 396.
          Banghart, M., et al. 2009. Angew Chem Int Ed Engl. 48, 9097.
          Product Information
          FormBrown solid
          Hill FormulaC₃₀H₄₆N₆O₆
          Chemical formulaC₃₀H₄₆N₆O₆
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetIon Channels
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Mourot, A., et al. 2012. Nat Methods. 9, 396.
          Banghart, M., et al. 2009. Angew Chem Int Ed Engl. 48, 9097.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2013 JSW
          Synonyms2,2'-((diazene-1,2-diylbis(4,1-phenylene))bis(azanediyl))bis(N,N,N-triethyl-2-oxoethanaminium) formate, Quaternary Ammonium–Azobenzene–Quaternary Ammonium
          DescriptionA membrane-impermeant Na+, K+, and Ca2+ channel blocker that is structurally composed of two azo-linked QX-314 (Cat. No. 552233) type quaternary amines. Both QX-314 and QAQ are shown to selectively target excitability of nociceptor neurons via TRPV1-dependent cellular uptake upon TRPV1 activation by Capsaicin (Cat. No. 211275). Unlike QX-314, the channel blocking potency of QAQ can be quickly switched off by an optical trans to cis isomerization upon 320 nm illumination, which in turn can be reversed back to the active trans configuration via 500 nm illumination. Its in vivo efficacy as a pain-selective, photochromic anesthetic has been demonstrated in modulating rat cornea tolerance to mechanical pressure (200 nmol QAQ/100 pmol Capsaicin/10 µl/eye). QAQ cellular uptake can also be achieved by ATP-activated P2X7 receptor, but not activated TRPA1 or TRPM8. In addition, QAQ is reported not to affect Kir (inward-rectifier) or HCN (hyperpolarization-activated cyclic nucleotide-gated) channels.
          FormBrown solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₀H₄₆N₆O₆
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMourot, A., et al. 2012. Nat Methods. 9, 396.
          Banghart, M., et al. 2009. Angew Chem Int Ed Engl. 48, 9097.