528282 | Polo-like Kinase Inhibitor I

528282
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₂H₂₁N₃O₆S₂916985-21-2

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      528282-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA thiophenecarboxamide compound that acts as a potent and ATP-binding site-targeting inhibitor of polo-like kinase 1 (IC50 = 126 nM) with excellent selectivity over IKK-2 and IKK-3 (IC50 > 16 µM).
          Catalogue Number528282
          Brand Family Calbiochem®
          SynonymsPlk Inhibitor I, 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(4-methanesulfonyl-benzyloxy)-thiophene-2-carboxamide
          References
          ReferencesBamborough, P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6236.
          Product Information
          CAS number916985-21-2
          ATP CompetitiveN
          FormTan solid
          Hill FormulaC₂₂H₂₁N₃O₆S₂
          Chemical formulaC₂₂H₂₁N₃O₆S₂
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetPolo-like Kinase
          Primary Target IC<sub>50</sub>126 nM against polo-like kinase 1
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          528282

          References

          Reference overview
          Bamborough, P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6236.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-April-2011 RFH
          SynonymsPlk Inhibitor I, 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(4-methanesulfonyl-benzyloxy)-thiophene-2-carboxamide
          DescriptionA thiophenecarboxamide compound that acts as a potent and ATP-binding site-targeting inhibitor of polo-like kinase 1 (IC50 = 126 nM) with excellent selectivity over IKK-2 and IKK-3 (IC50 > 16 µM).
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number916985-21-2
          Chemical formulaC₂₂H₂₁N₃O₆S₂
          Structure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesBamborough, P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6236.