851010 | PyBroP

851010
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Hill FormulaMolar Mass
      132705-51-2C₁₂H₂₄BrN₃P * F₆P466.19 g/mol

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      8510100025
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          Plastic bottle 25 g
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          8510100100
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              Plastic bottle 100 g
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              Description
              Catalogue Number851010
              Replaces01-62-0017
              Brand Family Novabiochem®
              Alternate Names
              • Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate
              Background InformationA superior reagent for rapid and effective coupling of N-methyl amino acids with low enantiomerization and for other critical applications [1-8].

              The coupling of N-methyl amino acids is difficult, and usually only gives low to moderate yields of products which are often contaminated with unwanted diastereomers. Many coupling reagents are ineffective or not practical to use: BOP and HOBt are often useless; BOP-Cl, pivaloyl chloride and Dpp-Cl require long reaction times and preactivation at 0°C.

              For coupling α-aminoisobutyric acid (Aib), PyBroP® is most effective when used with dimethylaminopyridine (DMAP) [3].

              The product number for this product was previously 01-62-0017.

              To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
              References
              Product Information
              CAS number132705-51-2
              Hill FormulaC₁₂H₂₄BrN₃P * F₆P
              Molar Mass466.19 g/mol
              HS Code2933 99 80
              Structure formula ImageStructure formula Image
              Applications
              ApplicationPyBroP Novabiochem®. CAS 132705-51-2, molar mass 466.19 g/mol.
              Biological Information
              Physicochemical Information
              Melting Point>100 °C
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Storage class10 - 13 Other liquids and solids
              WGKWGK 2 water endangering
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at +2°C to +8°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Color (visual)white to slight yellow to beige
              Appearance of substance (visual)powder
              Identity (IR)passes test
              Assay (HPLC, area%)≥ 98.0 % (a/a)

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              Product Number PackagingSpecificationLot Number
              8510100025 Plastic bottlePDF Specification Document
              8510100100 Plastic bottlePDF Specification Document

              Brochure

              Title
              Novabiochem Coupling Reagent Flyer 2010
              Novabiochem Innovations 03/10

              Citations

              Title
              • [1] J. Coste, et al. in 'Peptides, Chemistry, Structure & Biology, Proc. 11th American Peptide Symposium', J. E. Rivier & G. R. Marshall (Eds), ESCOM, Leiden, 1990, pp. 900.
              • [2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 669.
              • [3] J. Coste, et al. in 'Peptides 1990, Proc. 21st European Peptide Symposium', E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp. 76.
              • [4] J. Coste, et al. (1991) Tetrahedron Lett., 32, 1967.
              • [5] P. W. Baures, et al. (1997) J. Peptide Res., 50, 1.
              • [6] T. Doi, et al. (1999) Synlett, 11, 1751.
              • [7] A. M. Boldi, et al. (2001) J. Comb. Chem., 3, 367.
              • [8] S. Gazal, et al. (2001) J. Peptide Res., 58, 527.