03-0014-07 | SMC™ Human IL-21 Immunoassay Kit
IMMUNOASSAY KIT

03-0014-07
96-well strip plate  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey Applications
      HSingle Molecule Counting
      Description
      Catalogue Number03-0014-07
      Trade Name
      • SMC™
      DescriptionSMC™ Human IL-21 Immunoassay Kit
      IMMUNOASSAY KIT
      OverviewThe SMC™ IL-21 Immunoassay Kit contains all reagents required to perform the assay. This assay takes advantage of a standard immunoassay workflow configured in a standard plate format. Assay protocols are similar to existing sandwich ELISA methods with two key differences: 1) Elution buffer disrupts the sandwich, separating the labeled detection antibody for quantification. 2) The SMC™ immunoassay system detects analytes using Single Molecule Counting (SMC™) technology.
      Background InformationInterleukin-21 (IL-21) is a cytokine with a potent regulatory effect on the immune system. Mainly produced by activated T-cells, IL-21 is responsible for the hematopoiesis of T-, B-, natural killer and dendritic cells. The production and differentiation of these effector cells may lead to an increased immunity against cancerous or virally infected cells. Thus, the role of IL-21 in the regulation of immuno-inflammatory responses has important implications for diseases such as multiple sclerosis, metastatic melanoma and metastatic renal cell carcinoma. Thus IL-21 will remain an attractive subject for drug development. Successful study outcomes will further establish IL-21 immunotherapy as an effective treatment for various cancers and inflammatory diseases.
      References
      Product Information
      Components
      • Human IL-21 Coated Beads
      • Standard Diluent
      • Assay Buffer
      • Human IL-21 Standard
      • Human IL-21 Labeled Detection Antibody
      • SMC™ IL-21 Immunoassay Kit Instructions
      • 10X Wash Buffer
      • Elution Buffer B
      • Buffer C
      Precision, %
      • Low-end CV% Range: 1-11%
      • Low-end CV% Average: 7%
      Applications
      ApplicationThe sensitivity of Single Molecule Counting (SMC™) technology gives the SMC™ Human IL-21 Immunoassay Kit unparalleled performance in the quantification of IL-21 in human serum.
      Key Applications
      • Single Molecule Counting
      Biological Information
      Species Reactivity
      • Human
      Accuracy
      • Minimum of 10 samples spiked with acceptable recovery between 80-120%.
      Physicochemical Information
      Linearity of DilutionMinimum of 10 samples spiked and diluted (at least 3 dilutions) with acceptable recovery between 80-120%.
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size96-well strip plate
      Transport Information
      Supplemental Information
      Specifications