03-0112-00 | SMC™ Interleukin 23 (IL-23)
IMMUNOASSAY KIT

03-0112-00
96-well strip plate  
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      Overview

      Replacement Information

      Key Spec Table

      Analytes AvailableSpecies ReactivityKey Applications
      IL-23HSingle Molecule Counting
      Description
      Catalogue Number03-0112-00
      Trade Name
      • SMC™
      DescriptionSMC™ Interleukin 23 (IL-23)
      IMMUNOASSAY KIT
      OverviewThe SMC™ IL-23 Immunoassay Kit contains all reagents required to perform the assay. This assay takes advantage of a standard immunoassay workflow configured in a standard plate format. Assay protocols are similar to existing sandwich ELISA methods with two key differences: 1) Elution buffer disrupts the sandwich, separating the labeled detection antibody for quantification. 2) The SMC™ immunoassay system detects analytes using Single Molecule Counting (SMC™) technology.
      Background InformationInterleukin-23 (IL-23) is an endogenous cytokine responsible for the production of IL-17 from memory T-lymphocytes. The active human form of IL-23 is heterodimeric, consisting of a p40 subunit shared with IL-12, and a p19 subunit unique to IL-23. The p19 subunit is expressed by T-lymphocytes, activated macrophages, dendritic and endothelial cells. IL-23 also promotes upregulation of MMP-9 and the stimulation of helper T-lymphocytes to Th17 cells. The proinflammatory characteristics of IL-23 make it a target of interest for a number of Th17 autoimmune disorders, including Crohn’s disease, colitis, inflammatory bowel disease, and psoriasis.
      References
      Product Information
      Components
      • Assay Buffer
      • Human IL-23 Coated Beads
      • Standard Diluent
      • Human IL-23 Detection Antibody
      • Human IL-23 Standard
      • SMC™ Human IL-23 Immunoassay Kit Instructions
      • 10X Wash Buffer
      • Elution Buffer B
      • Buffer D
      Precision, %
      • Low-end CV% Range: 0-13%
      • Low-end CV% Average: 6%
      Applications
      ApplicationThe sensitivity of Single Molecule Counting (SMC™) technology gives the SMC™ Human IL-23 Immunoassay Kit unparalleled performance in the quantification of IL-23 in human EDTA plasma and serum.
      Key Applications
      • Single Molecule Counting
      Biological Information
      Species Reactivity
      • Human
      Analytes Available
      • IL-23
      Accuracy
      • Minimum of 10 samples spiked with acceptable recovery between 80-120%.
      Physicochemical Information
      Linearity of DilutionMinimum of 10 samples spiked and diluted (at least 3 dilutions) with acceptable recovery between 80-120%.
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size96-well strip plate
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protocols

      Title
      Erenna SMC Human IL-23 Immunoassay Kit Instructions

      SDS

      Title

      Safety Data Sheet (SDS) 

      Brochure

      Title
      Custom Immunoassay Menu of Services
      SMCxPRO™ Immunoassay System - Sensitivity You can Count On
      Singulex Erenna® Immunoassay System

      Technical Info

      Title
      96 well Template 2 Up
      96 well Template Single
      Application Note: Improved performance with conversion from ELISA to an Erenna® Immunoassay (MM)
      Singulex Erenna® single molecule counting immunoassays outperform electrochemiluminescence (ECL) methods

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      Categories

      Life Science Research > Protein Detection and Quantification > Immunoassays > Enzyme-linked Immunosorbent Assay (ELISA) > Complete ELISA Kits
      Life Science Research > Antibodies and Assays > Immunoassays > Enzyme-linked Immunosorbent Assay (ELISA) > Complete ELISA Kits