508839 | Telomerase Inhibitor X, BIBR1532 - CAS 321674-73-1 - Calbiochem

508839
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₁H₁₇NO₃321674-73-1

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      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5.08839.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number508839
          Brand Family Calbiochem®
          SynonymsBIBR 1532, BIBR-1532
          References
          ReferencesDamm, K., et al. 2001. The. EMBO J. 20, 6958.
          Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
          Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.
          Product Information
          CAS number321674-73-1
          FormOff-white solid
          Hill FormulaC₂₁H₁₇NO₃
          Chemical formulaC₂₁H₁₇NO₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetTeomerase
          Primary Target IC<sub>50</sub>93 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Damm, K., et al. 2001. The. EMBO J. 20, 6958.
          Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
          Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2014 JSW
          SynonymsBIBR 1532, BIBR-1532
          DescriptionA cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number321674-73-1
          Chemical formulaC₂₁H₁₇NO₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDamm, K., et al. 2001. The. EMBO J. 20, 6958.
          Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
          Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.