124012 | Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

124012
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₃H₁₆N₆O₄35943-35-2

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      124012-10MG
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          10 mg
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          124012-1MG
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              1 mg
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              Description
              Overview A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038).
              Catalogue Number 124012
              Brand Family Calbiochem®
              Synonyms NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
              References
              References Karst, A., et al. 2006. Cancer Res. 66, 9225.
              Yang, L., et al. 2004. Cancer Res. 64, 4394.
              Product Information
              CAS number 35943-35-2
              ATP Competitive N
              Form Solid
              Hill Formula C₁₃H₁₆N₆O₄
              Chemical formula C₁₃H₁₆N₆O₄
              Molar Mass 320.3
              Reversible Y
              Structure formula Image
              Applications
              Biological Information
              Primary Target Akt1, Akt 2, Akt3
              Purity ≥95% by HPLC
              Physicochemical Information
              Cell permeable Y
              Solubility DMSO
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECS RY8455000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
              Toxicity Carcinogenic / Teratogenic
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze No
              Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              MSDS

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              Certificates of Analysis

              TitleLot Number
              124012

              References

              Reference overview
              Karst, A., et al. 2006. Cancer Res. 66, 9225.
              Yang, L., et al. 2004. Cancer Res. 64, 4394.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision 16-January-2012 RFH
              Synonyms NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
              Description A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038.
              Form Solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number 35943-35-2
              RTECS RY8455000
              Molar mass 320.3
              Chemical formula C₁₃H₁₆N₆O₄
              Structure formula
              Purity ≥95% by HPLC
              Solubility DMSO (10 mg/ml). Further dilute at aqueous buffer in low micromolar concentrations.
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze No
              Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Carcinogenic / Teratogenic
              References Karst, A., et al. 2006. Cancer Res. 66, 9225.
              Yang, L., et al. 2004. Cancer Res. 64, 4394.