172060 | Andrographolide - CAS 5508-58-7 - Calbiochem

172060
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₂₀H₃₀O₅5508-58-7

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      172060-50MG
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          50 mg
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          Description
          Overview A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
          Catalogue Number 172060
          Brand Family Calbiochem®
          Synonyms Andro
          References
          References Xia, Y.F., et al. 2004. J. Immunol. 173, 4207.
          Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
          Yu, B.C., et al. 2003. Planta Med. 69, 1075.
          Product Information
          CAS number 5508-58-7
          ATP Competitive N
          Form Off-white solid
          Hill Formula C₂₀H₃₀O₅
          Chemical formula C₂₀H₃₀O₅
          Molar Mass 350.5
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target NF-κB and AP-1 activation
          Primary Target IC<sub>50</sub> ≤ 15 µM against NF-κB and AP-1 activation
          Purity ≥95% by TLC
          Physicochemical Information
          Cell permeable N
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECS LU3490750
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          172060
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 14-April-2008 RFH
          Synonyms Andro
          Description An irreversible blocker of NF-κB and AP-1 (IC50 ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.
          Form Off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 5508-58-7
          RTECS LU3490750
          Molar mass 350.5
          Chemical formula C₂₀H₃₀O₅
          Structure formula
          Purity ≥95% by TLC
          Solubility DMSO (15 mg/ml) or Chloroform:Methanol (1:1) (10 mg/ml). Use only fresh DMSO.
          Storage +2°C to +8°C
          Protect from light
          No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index 14, 633
          References Xia, Y.F., et al. 2004. J. Immunol. 173, 4207.
          Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
          Yu, B.C., et al. 2003. Planta Med. 69, 1075.