176901 | Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem

176901
Price could not be retrieved
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited Availability Limited Availability
Discontinued
There is a newer version of this product
Limited Quantities Available
Availability to be confirmed
      Will advise
      View Pricing & Availability
         CompareClick To Print This Page

      Overview

      Key Spec Table

      Empirical Formula
      C₈₁H₁₅₀N₄₂O₁₇

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      176901-1MG
      Retrieving availability...
      Limited Availability Limited Availability
      Discontinued
      There is a newer version of this product
      Limited Quantities Available
      Availability to be confirmed
          Will advise

          1 mg
          Retrieving price...
          Price could not be retrieved
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          Overview A cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells.
          Catalogue Number 176901
          Brand Family Calbiochem®
          Synonyms Anthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
          References
          References Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
          Tonello, F., et. al. 2002. Nature 418, 386.
          Product Information
          Form White lyophilized solid
          Formulation Supplied as a trifluoroacetate salt.
          Hill Formula C₈₁H₁₅₀N₄₂O₁₇
          Chemical formula C₈₁H₁₅₀N₄₂O₁₇
          Molar Mass 1984.4
          Hygroscopic Hygroscopic
          Peptide Sequence Ac-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
          Applications
          Application The Anthrax Lethal Factor Protease Inhibitor, In-2-LF controls the biological activity of Anthrax Lethal Factor Protease. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
          Biological Information
          Primary Target anthrax LF metalloprotease
          Primary Target K<sub>i</sub> 1 nM against Anthrax lethal factor (LF) metalloprotease
          Purity ≥97% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO, 5% Acetic acid, or H₂O
          Peptide Sequence Ac-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

          Languages
          Danmark Deutschland Ellas
          English España France
          Italia Korea Magyarország
          Nederland  Norge Polska
          Portugal Suomi Sverige
          България

          Certificates of Analysis

          TitleLot Number
          176901
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 14-April-2008 RFH
          Synonyms Anthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
          Description A cell-permeable derivative of a 14-mer peptide that is based on the MEK-2 template and acts as a competitive inhibitor of Anthrax lethal factor metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Exhibits protective effects against Anthrax toxin-induced cytotoxicity in RAW264.7 and J772.A1 cells. Reported to competitively inhibit furin (Ki = 49 nM.
          Form White lyophilized solid
          Formulation Supplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Molar mass 1984.4
          Chemical formula C₈₁H₁₅₀N₄₂O₁₇
          Peptide Sequence Ac-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
          Purity ≥97% by HPLC
          Solubility DMSO (5 mg/ml), 5% Acetic Acid (5 mg/ml), or H₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          References Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
          Tonello, F., et. al. 2002. Nature 418, 386.