219439 | Anti-c-Cbl Mouse mAb (5C4)

219439
  
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      Overview

      Key Spec Table

      Host
      M
      Description
      Overview Recognizes the ~120 kDa c-Cbl protein.
      Catalogue Number 219439
      Brand Family Calbiochem®
      References
      Product Information
      Form Lyophilized
      Formulation Lyophilized from 2X PBS, PEG, sucrose.
      Preservative ≤0.1% sodium azide
      Applications
      Key Applications Enzyme-Linked Immunosorbent Assay
      Immunoblotting (Western Blotting)
      Biological Information
      Immunogen a synthetic peptide corresponding to amino acids 695-705 of human c-Cbl, conjugated to KLH
      Immunogen species Human
      Clone 5C4
      Host Mouse
      Isotype IgG₁
      Species human, mouse
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze No
      Special Instructions Reconstitute with 1 ml dH₂O. Following reconstitution, refrigerate (4°C) for short-term storage or aliquot, flash-freeze in liquid nitrogen, and freeze (-70°C) for long-term storage. Stock solutions are stable for up to 3 months at 4°C or for up to 1 year at -70°C. Thaw aliquots at 37°C. Avoid freeze/thaw cycles of solution.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MSDS

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      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision 26-July-2007 RFH
      Application ELISA (0.05 µg/ml) Immunoblotting (1 µg/ml, colorimetric; 0.5 µg/ml, chemiluminescence)
      Description Mouse monoclonal antibody purified by thiophilic adsorption and size exclusion chromatography. Recognizes the ~120 kDa c-Cbl protein.
      Background Cbl proteins are involved in the negative regulation of receptor tyrosine kinases (EGFR, PDGFR), cytokine receptors, and immunoreceptors (T, B, Fc receptors). At least for EGFR and PDGFR, recruitment of tyrosine-phosphorylated c-cbl to the activated receptor complex leads to enhanced ubiquitinylation and degradation of the activated receptor.
      Host Mouse
      Immunogen species Human
      Immunogen a synthetic peptide corresponding to amino acids 695-705 of human c-Cbl, conjugated to KLH
      Clone 5C4
      Isotype IgG₁
      Species human, mouse
      Form Lyophilized
      Formulation Lyophilized from 2X PBS, PEG, sucrose.
      Preservative ≤0.1% sodium azide
      Comments Variables associated with assay conditions will dictate the proper working dilution.
      Storage -20°C
      No
      Special Instructions Reconstitute with 1 ml dH₂O. Following reconstitution, refrigerate (4°C) for short-term storage or aliquot, flash-freeze in liquid nitrogen, and freeze (-70°C) for long-term storage. Stock solutions are stable for up to 3 months at 4°C or for up to 1 year at -70°C. Thaw aliquots at 37°C. Avoid freeze/thaw cycles of solution.
      Toxicity Standard Handling