118500 | ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem

118500
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₂₁H₁₇NO₃S₂587871-26-9

      Pricing & Availability

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      118500-10MG
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          10 mg
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          118500-2MG
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              2 mg
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              Description
              Overview A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5 , 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 = µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502) in DMSO is also available.
              Catalogue Number 118500
              Brand Family Calbiochem®
              Synonyms 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
              References
              References Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
              Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
              Hickson, I., et al. 2004. Cancer Res. 64, 9152.
              Product Information
              CAS number 587871-26-9
              ATP Competitive Y
              Form White solid
              Hill Formula C₂₁H₁₇NO₃S₂
              Chemical formula C₂₁H₁₇NO₃S₂
              Molar Mass 395.5
              Structure formula Image
              Applications
              Application The ATM Kinase Inhibitor, also referenced under CAS 587871-26-9, controls the biological activity of ATM Kinase. This small molecule/inhibitor is primarily used for Cell Structure applications.
              Biological Information
              Primary Target ATM Kinase
              Primary Target IC<sub>50</sub> 13 nM
              Primary Target K<sub>i</sub> 2.2 nM for ATM kinase
              Purity ≥98% by HPLC
              Physicochemical Information
              Cell permeable Y
              Solubility DMSO
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped with Blue Ice or with Dry Ice
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              MSDS

              Languages
              English

              Certificates of Analysis

              TitleLot Number
              118500
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision 06-February-2014 JSW
              Synonyms 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
              Description A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
              Form White solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number 587871-26-9
              Molar mass 395.5
              Chemical formula C₂₁H₁₇NO₃S₂
              Structure formula
              Purity ≥98% by HPLC
              Solubility DMSO (4 mg/ml)
              Storage -20°C
              Protect from light
              Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Standard Handling
              References Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
              Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
              Hickson, I., et al. 2004. Cancer Res. 64, 9152.