208734 | Calmodulin Binding Domain - CAS 115044-69-4 - Calbiochem

208734
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      Overview

      Key Spec Table

      Empirical Formula CAS #
      C₁₀₃H₁₈₅N₃₁O₂₄S115044-69-4

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      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      208734-1MG
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          1 mg
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          Description
          Overview Potent calmodulin antagonist. Inhibits activation of calmodulin-dependent protein kinase II (IC50 = 52 nM). Interacts with the catalytic core of CaM kinase II as a pseudosubstrate.
          Catalogue Number 208734
          Brand Family Calbiochem®
          Synonyms Calmodulin antagonist, CaM kinase II 290-309
          References
          References James, P., et al. 1995. Trends Biochem. Sci. 20, 38.
          Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
          Yazawa, M., et al. 1992. Biochemistry 31, 3171.
          Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.
          Product Information
          CAS number 115044-69-4
          ATP Competitive N
          Form White lyophilized solid
          Formulation Supplied as a trifluoroacetate salt.
          Hill Formula C₁₀₃H₁₈₅N₃₁O₂₄S
          Chemical formula C₁₀₃H₁₈₅N₃₁O₂₄S
          Molar Mass 2274.3
          Hygroscopic Hygroscopic
          Peptide Sequence H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
          Reversible N
          Sold on the basis of peptide content Yes
          Applications
          Biological Information
          Primary Target Calmodulin dependent Protein Kinase-2
          Primary Target IC50 52 nM against calmodulin-dependent protein kinase II
          Purity ≥95% by HPLC
          Physicochemical Information
          Cell permeable N
          Solubility H₂O
          Peptide Content Yes
          Peptide Sequence H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          208734

          References

          Reference overview
          James, P., et al. 1995. Trends Biochem. Sci. 20, 38.
          Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
          Yazawa, M., et al. 1992. Biochemistry 31, 3171.
          Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.

          Brochure

          Title
          Calmodulin and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 28-May-2008 RFH
          Synonyms Calmodulin antagonist, CaM kinase II 290-309
          Description A potent calmodulin antagonist that inhibits Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM) and Ca2+/calmodulin-dependent phosphodiesterase (IC50 = 1.1 nM).
          Form White lyophilized solid
          Formulation Supplied as a trifluoroacetate salt.
          CAS number 115044-69-4
          Molar mass 2274.3
          Chemical formula C₁₀₃H₁₈₅N₃₁O₂₄S
          Peptide Sequence H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
          Purity ≥95% by HPLC
          Solubility H₂O
          Storage -20°C
          Hygroscopic
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
          Toxicity Standard Handling
          References James, P., et al. 1995. Trends Biochem. Sci. 20, 38.
          Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
          Yazawa, M., et al. 1992. Biochemistry 31, 3171.
          Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.