627610 | Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem

627610
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula CAS #
      C₂₂H₃₀FN₃O₇187389-52-2

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      627610-1MG
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          1 mg
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          627610-5MG
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              5 mg
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              Description
              Overview A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells. Shown to enhance the freeze-thaw survival of human embryonic stem cells. When using with purified native or recombinant enzyme, pre-treatment with an esterase is required.
              Catalogue Number 627610
              Brand Family Calbiochem®
              Synonyms Z-VAD (OMe)-FMK
              References
              References Heng, B.C., et al. 2007. Biosci. Rep. 27, 257.
              Martin, U., et al. 2007. Apoptosis 12, 525.
              Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.
              Joo, C., et al. 1999. Ophthalmic Res. 31, 287.
              McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229.
              Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312.
              Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735.
              An, S. and Know, K.A. 1996. FEBS Lett. 386, 115.
              Cain, K., et al. 1996. Biochem J. 314, 27.
              Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266.
              Pronk, G.J., et al. 1996. Science 271, 808.
              Slee, E.A., et al. 1996. Biochem. J. 315, 21.
              Chow, S.C., et al. 1995. FEBS Lett. 364, 134.
              Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283.
              Zhu, H., et al. 1995. FEBS Lett. 374, 303.
              Product Information
              CAS number 187389-52-2
              ATP Competitive N
              Form White solid
              Hill Formula C₂₂H₃₀FN₃O₇
              Chemical formula C₂₂H₃₀FN₃O₇
              Molar Mass 467.5
              Peptide Sequence Z-Val-Ala-Asp(OMe)-CH₂F*
              Reversible N
              Structure formula Image
              Applications
              Biological Information
              Primary Target Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells
              Purity Single spot by TLC
              Physicochemical Information
              Cell permeable Y
              Solubility DMSO
              Peptide Sequence Z-Val-Ala-Asp(OMe)-CH₂F*
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze No
              Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              MSDS

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              Certificates of Analysis

              TitleLot Number
              627610

              References

              Reference overview
              Heng, B.C., et al. 2007. Biosci. Rep. 27, 257.
              Martin, U., et al. 2007. Apoptosis 12, 525.
              Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.
              Joo, C., et al. 1999. Ophthalmic Res. 31, 287.
              McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229.
              Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312.
              Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735.
              An, S. and Know, K.A. 1996. FEBS Lett. 386, 115.
              Cain, K., et al. 1996. Biochem J. 314, 27.
              Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266.
              Pronk, G.J., et al. 1996. Science 271, 808.
              Slee, E.A., et al. 1996. Biochem. J. 315, 21.
              Chow, S.C., et al. 1995. FEBS Lett. 364, 134.
              Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283.
              Zhu, H., et al. 1995. FEBS Lett. 374, 303.

              Citations

              Title
            • Heng, B.C., et al. 2007. Biosci. Rep. 27, 257.
            • Naohide Watanabe and Eric Lam. 2005. Journal of Biological Chemistry 280, 14691.
            • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision 27-February-2012 RFH
              Synonyms Z-VAD (OMe)-FMK
              Description A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required.
              Form White solid
              CAS number 187389-52-2
              Molar mass 467.5
              Chemical formula C₂₂H₃₀FN₃O₇
              Peptide Sequence Z-Val-Ala-Asp(OMe)-CH₂F*
              Structure formula
              Purity Single spot by TLC
              Solubility DMSO (50 mM)
              Storage -20°C
              Protect from moisture
              Do Not Freeze No
              Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
              Toxicity Standard Handling
              References Heng, B.C., et al. 2007. Biosci. Rep. 27, 257.
              Martin, U., et al. 2007. Apoptosis 12, 525.
              Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.
              Joo, C., et al. 1999. Ophthalmic Res. 31, 287.
              McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229.
              Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312.
              Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735.
              An, S. and Know, K.A. 1996. FEBS Lett. 386, 115.
              Cain, K., et al. 1996. Biochem J. 314, 27.
              Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266.
              Pronk, G.J., et al. 1996. Science 271, 808.
              Slee, E.A., et al. 1996. Biochem. J. 315, 21.
              Chow, S.C., et al. 1995. FEBS Lett. 364, 134.
              Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283.
              Zhu, H., et al. 1995. FEBS Lett. 374, 303.
              Citation
            • Heng, B.C., et al. 2007. Biosci. Rep. 27, 257.
            • Naohide Watanabe and Eric Lam. 2005. Journal of Biological Chemistry 280, 14691.
            • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.