232120 | Cisplatin - CAS 15663-27-1 - Calbiochem

232120
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      Pt(NH₃)₂Cl₂15663-27-1

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      232120-50MG
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      Discontinued
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          50 mg
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          Description
          Overview A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

          Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
          Catalogue Number 232120
          Brand Family Calbiochem®
          Synonyms CPDC, DDP, cis-Diaminedichloroplatinum
          References
          References Hall, M.D., et al. 2014. Cancer Res. In press.
          Duan, L., et al. 2001. J. Neurooncol. 52, 23.
          Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
          Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.
          Product Information
          CAS number 15663-27-1
          ATP Competitive N
          Form Yellow solid
          Hill Formula Pt(NH₃)₂Cl₂
          Chemical formula Pt(NH₃)₂Cl₂
          Molar Mass 300.0
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target Induces apoptosis in cancer cells
          Purity ≥98% by HPLC
          Physicochemical Information
          Cell permeable N
          Solubility DMSO, H₂O with 154 mM NaCl, or PBS with 140 mM NaCl
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECS TP2450000
          Safety Information
          R Phrase R: 25-36/37/38-45-42/43

          Toxic if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause cancer.
          May cause sensitization by inhalation and skin contact.
          S Phrase S: 22-24-37-45-53

          Do not breathe dust.
          Avoid contact with skin.
          Wear suitable gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze No
          Special Instructions Unstable in solution; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          232120
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 08-July-2014 JSW
          Synonyms CPDC, DDP, cis-Diaminedichloroplatinum
          Description A platinum coordination complex with potent antineoplastic activity.

          Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
          Form Yellow solid
          CAS number 15663-27-1
          RTECS TP2450000
          Molar mass 300.0
          Chemical formula Pt(NH₃)₂Cl₂
          Structure formula
          Purity ≥98% by HPLC
          Solubility DMSO (10 mg/ml), H₂O with 154 mM NaCl (1 mg/ml), or PBS with 140 mM NaCl (1 mg/ml)
          Storage +2°C to +8°C
          No
          Special Instructions Unstable in solution; reconstitute just prior to use.
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index 14, 2317
          References Hall, M.D., et al. 2014. Cancer Res. In press.
          Duan, L., et al. 2001. J. Neurooncol. 52, 23.
          Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
          Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother. 16, 279.