239764 | Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

239764
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₅H₂₃NO₄66-81-9

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      239764-100MG
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          100 mg
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          239764-1GM
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              1 gm
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              Description
              Overview Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions. Also available as a 300 mM solution in DMSO (Cat. No. 508739).
              Catalogue Number 239764
              Brand Family Calbiochem®
              References
              References Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.
              Product Information
              CAS number 66-81-9
              Form White solid
              Hill Formula C₁₅H₂₃NO₄
              Chemical formula C₁₅H₂₃NO₄
              Molar Mass 281.3
              Structure formula Image
              Applications
              Biological Information
              Primary Target hFKBP12
              Primary Target K<sub>i</sub> 3.4 µM
              Purity ≥98% by HPLC
              Physicochemical Information
              Solubility EtOH or MeOH
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECS MA4375000
              Safety Information
              R Phrase R: 28-40-51/53-61

              Very toxic if swallowed.
              Limited evidence of a carcinogenic effect.
              Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
              May cause harm to the unborn child.
              S Phrase S: 45-53-61

              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Avoid exposure - obtain special instructions before use.
              Avoid release to the environment. Refer to special instructions/safety data sheet.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Highly Toxic & Carcinogenic / Teratogenic
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage +15°C to +30°C
              Do not freeze No
              Special Instructions Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              MSDS

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              Certificates of Analysis

              TitleLot Number
              239764

              References

              Reference overview
              Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.

              Brochure

              Title
              Tools and Tips for Analyzing Apoptosis

              Citations

              Title
            • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision 29-April-2008 RFH
              Description Antifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
              Form White solid
              CAS number 66-81-9
              RTECS MA4375000
              Molar mass 281.3
              Chemical formula C₁₅H₂₃NO₄
              Structure formula
              Purity ≥98% by HPLC
              Solubility Chloroform, Ethanol, and Methanol
              Storage +15°C to +30°C
              Do Not Freeze No
              Special Instructions Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
              Toxicity Highly Toxic & Carcinogenic / Teratogenic
              Merck USA index 14, 2728
              References Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.
              Citation
            • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.