138000 | D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem

138000
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      Overview

      Key Spec Table

      Empirical Formula CAS #
      C₇H₅NO₂S39793-31-2

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      138000-50MG
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          50 mg
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          Description
          Overview A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
          Catalogue Number 138000
          Brand Family Calbiochem®
          Synonyms 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8
          References
          References Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328, 921.
          Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3386.
          Product Information
          CAS number 39793-31-2
          Form Beige solid
          Hill Formula C₇H₅NO₂S
          Chemical formula C₇H₅NO₂S
          Molar Mass 167.2
          Structure formula Image
          Applications
          Biological Information
          Purity ≥97% by HPLC
          Physicochemical Information
          Solubility DMSO or 5% NaOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R Phrase R: 22-36/37/38

          Harmful if swallowed.
          Irritating to eyes, respiratory system and skin.
          S Phrase S: 26-36/37/39

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Unstable in solution; reconstitute just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          138000

          References

          Reference overview
          Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328, 921.
          Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3386.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 25-August-2009 RFH
          Synonyms 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8
          Description A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
          Form Beige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 39793-31-2
          Molar mass 167.2
          Chemical formula C₇H₅NO₂S
          Structure formula
          Purity ≥97% by HPLC
          Solubility DMSO (80 mg/ml) or 5% NaOH (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze No
          Special Instructions Unstable in solution; reconstitute just prior to use.
          Toxicity Harmful
          References Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328, 921.
          Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3386.