341207 | ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

341207
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₇H₅₈NO₆P70641-51-9

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      341207-50MG
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          Plastic ampoule 50 mg
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          341207-5MG
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              Description
              OverviewA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
              Catalogue Number341207
              Brand Family Calbiochem®
              SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
              References
              ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
              Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
              Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
              Helfman, D., et al. 1993. Cancer Res. 53, 2955.
              Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
              Powis, G., et al. 1992. Cancer Res. 52, 2835.
              Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
              Product Information
              CAS number70641-51-9
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₂₇H₅₈NO₆P
              Chemical formulaC₂₇H₅₈NO₆P
              ReversibleY
              Structure formula Image
              Applications
              Biological Information
              Primary TargetPI-PLC
              Primary Target IC<sub>50</sub>9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
              Purity≥95% by TLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSYK0718000
              Safety Information
              R PhraseR: 40

              Limited evidence of a carcinogenic effect.
              S PhraseS: 22-36

              Do not breathe dust.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Carcinogenic / Teratogenic
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              341207

              References

              Reference overview
              Harguindey, J., et al. 2000. Apoptosis 5, 87.
              Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
              Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
              Helfman, D., et al. 1993. Cancer Res. 53, 2955.
              Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
              Powis, G., et al. 1992. Cancer Res. 52, 2835.
              Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.

              Brochure

              Title
              Nitric Oxide and Oxidative Stress Brochure
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision23-May-2011 JSW
              SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
              DescriptionA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Inhibits protein kinase C from various leukemic cells. Also promotes rapid and selective apoptosis in human leukemic cells. Has strong antitumor and anticancer properties.
              FormWhite solid
              CAS number70641-51-9
              RTECSYK0718000
              Chemical formulaC₂₇H₅₈NO₆P
              Structure formula
              Purity≥95% by TLC
              SolubilityDMSO (5 mg/ml), CHCl₃ (50 mg/ml), Ethanol (5 mg/ml), or H₂O. Material may form micelles in aqueous stock solutions, which may affect experimental results.
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
              Toxicity Carcinogenic / Teratogenic
              ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
              Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
              Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
              Helfman, D., et al. 1993. Cancer Res. 53, 2955.
              Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
              Powis, G., et al. 1992. Cancer Res. 52, 2835.
              Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.