341207 | ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

341207
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₂₇H₅₈NO₆P70641-51-9

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      341207-5MG
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          5 mg
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          Description
          Overview A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
          Catalogue Number 341207
          Brand Family Calbiochem®
          Synonyms Edelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
          References
          References Harguindey, J., et al. 2000. Apoptosis 5, 87.
          Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
          Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
          Helfman, D., et al. 1993. Cancer Res. 53, 2955.
          Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
          Powis, G., et al. 1992. Cancer Res. 52, 2835.
          Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
          Product Information
          CAS number 70641-51-9
          ATP Competitive N
          Form White solid
          Hill Formula C₂₇H₅₈NO₆P
          Chemical formula C₂₇H₅₈NO₆P
          Molar Mass 523.7
          Reversible Y
          Structure formula Image
          Applications
          Biological Information
          Primary Target PI-PLC
          Primary Target IC<sub>50</sub> 9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
          Purity ≥95% by TLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO, CHCl₃, EtOH, or H₂O
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECS YK0718000
          Safety Information
          R Phrase R: 40

          Limited evidence of a carcinogenic effect.
          S Phrase S: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Do not freeze No
          Special Instructions Following reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          341207

          References

          Reference overview
          Harguindey, J., et al. 2000. Apoptosis 5, 87.
          Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
          Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
          Helfman, D., et al. 1993. Cancer Res. 53, 2955.
          Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
          Powis, G., et al. 1992. Cancer Res. 52, 2835.
          Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 23-May-2011 JSW
          Synonyms Edelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
          Description A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Inhibits protein kinase C from various leukemic cells. Also promotes rapid and selective apoptosis in human leukemic cells. Has strong antitumor and anticancer properties.
          Form White solid
          CAS number 70641-51-9
          RTECS YK0718000
          Molar mass 523.7
          Chemical formula C₂₇H₅₈NO₆P
          Structure formula
          Purity ≥95% by TLC
          Solubility DMSO (5 mg/ml), CHCl₃ (50 mg/ml), Ethanol (5 mg/ml), or H₂O. Material may form micelles in aqueous stock solutions, which may affect experimental results.
          Storage -20°C
          Do Not Freeze No
          Special Instructions Following reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
          Toxicity Carcinogenic / Teratogenic
          References Harguindey, J., et al. 2000. Apoptosis 5, 87.
          Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
          Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
          Helfman, D., et al. 1993. Cancer Res. 53, 2955.
          Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
          Powis, G., et al. 1992. Cancer Res. 52, 2835.
          Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.