361556 | GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem

361556
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₇H₁₂BrN₃O₂710323-61-8

      Pricing & Availability

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      361556-1MG
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          1 mg
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          Description
          Overview A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC50 > 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
          Catalogue Number 361556
          Brand Family Calbiochem®
          Synonyms 1-Methyl-BIO
          References
          References Knockaert, M., et al. 2004. Oncogene 23, 4400.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
          Product Information
          CAS number 710323-61-8
          ATP Competitive N
          Form Dark red solid
          Hill Formula C₁₇H₁₂BrN₃O₂
          Chemical formula C₁₇H₁₂BrN₃O₂
          Molar Mass 370.2
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target Relevant kinase inactive control
          Primary Target IC<sub>50</sub> > 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β
          Purity ≥97% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          361556

          References

          Reference overview
          Knockaert, M., et al. 2004. Oncogene 23, 4400.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 12-April-2011 RFH
          Synonyms 1-Methyl-BIO
          Description A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3α/β (IC50 >92 µM for Cdk1/cyclin B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
          Form Dark red solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 710323-61-8
          Molar mass 370.2
          Chemical formula C₁₇H₁₂BrN₃O₂
          Structure formula
          Purity ≥97% by HPLC
          Solubility DMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          References Knockaert, M., et al. 2004. Oncogene 23, 4400.
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors