407601 | Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

407601
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      Overview

      Key Spec Table

      Empirical Formula CAS #
      C₂₀H₂₁N₅O₄509093-47-4

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      407601-5MG
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          5 mg
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          Description
          Overview A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602).
          Catalogue Number 407601
          Brand Family Calbiochem®
          Synonyms N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, IRAK-1/4 Inhibitor
          References
          References Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
          Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
          Product Information
          CAS number 509093-47-4
          ATP Competitive N
          Form Yellow crystalline solid
          Hill Formula C₂₀H₂₁N₅O₄
          Chemical formula C₂₀H₂₁N₅O₄
          Molar Mass 395.4
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target Interleukin-1 receptor-associated kinases
          Primary Target IC50 300 nM and 200 nM for IRAK-1 and -4
          Purity ≥98% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R Phrase R: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S Phrase S: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          407601

          References

          Reference overview
          Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
          Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 01-November-2012 JSW
          Synonyms N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, IRAK-1/4 Inhibitor
          Description A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src.
          Form Yellow crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 509093-47-4
          Molar mass 395.4
          Chemical formula C₂₀H₂₁N₅O₄
          Structure formula
          Purity ≥98% by HPLC
          Solubility DMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          References Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
          Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.