420132 | JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem

420132
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₆H₆Br₆1837-91-8

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      420132-25MG
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      Discontinued
      There is a newer version of this product
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          25 mg
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          Description
          Overview A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
          Catalogue Number 420132
          Brand Family Calbiochem®
          Synonyms 1,2,3,4,5,6-Hexabromocyclohexane
          References
          References Sandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526.
          Product Information
          CAS number 1837-91-8
          ATP Competitive N
          Form Off-white solid
          Hill Formula C₆H₆Br₆
          Chemical formula C₆H₆Br₆
          Molar Mass 557.5
          Reversible Y
          Structure formula Image
          Applications
          Biological Information
          Primary Target JAK2 autophosphorylation
          Purity ≥ 97% by GC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          420132

          References

          Reference overview
          Sandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 02-December-2010 RFH
          Synonyms 1,2,3,4,5,6-Hexabromocyclohexane
          Description A cell-permeable, specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2 that interacts with a solvent-accessible pocket near the activation loop of JAK2. Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
          Form Off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 1837-91-8
          Molar mass 557.5
          Chemical formula C₆H₆Br₆
          Structure formula
          Purity ≥ 97% by GC
          Solubility DMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          References Sandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526.