420120 | Juglone - CAS 481-39-0 - Calbiochem

420120
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₀H₆O₃481-39-0

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      420120-250MG
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          250 mg
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          Description
          Overview A highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family). Other known PPlase inhibitors such as cyclosporin A, FK506, and rapamycin are not reported to inhibit the parvulin family of PPlases. The inactivation is shown to occur via the addition of thiol groups to juglone and not by any redox process. Exhibits bacteriostatic and fungistatic effects. Reported to be cytotoxic towards eukaryotic cells and to block transcription by RNA polymerase II.
          Catalogue Number 420120
          Brand Family Calbiochem®
          Synonyms 5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone
          References
          References Chao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
          Hennig, L., et al. 1998. Biochemistry 37, 5953.
          Product Information
          CAS number 481-39-0
          Form Orange solid
          Hill Formula C₁₀H₆O₃
          Chemical formula C₁₀H₆O₃
          Molar Mass 174.2
          Structure formula Image
          Applications
          Application A highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family).
          Biological Information
          Primary Target PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family)
          Purity ≥95% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO or EtOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECS QJ5775000
          Safety Information
          R Phrase R: 36/37/38-25

          Irritating to eyes, respiratory system and skin.
          Toxic if swallowed.
          S Phrase S: 45-26

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Special Instructions Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          420120
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 13-May-2008 RFH
          Synonyms 5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone
          Description Originally isolated from the fruit shells and leaves of walnut trees, juglone is a highly selective, cell permeable, irreversible inhibitor of the parvulin family of peptidyl-prolyl cis/trans isomerases (PPIase). Functions by covalently modifying sulfhydryl groups in the target enzymes. Exhibits bacteriostatic and fungistatic properties as well as cytotoxicity in eukaryotic cells. Also reported to directly block transcription in eukaryotic cells by RNA polymerase I, II, and III as determined by nuclear run-off (IC50 = 7 µM, 7 µM, and 2 µM, respectively). Disrupts formation of functional pre-initiation complexes via modification of sulhydryl groups, but does not significantly affect initiation or elongation. Does not inhibit restriction endonucleases or T7 RNA polymerase.
          Form Orange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 481-39-0
          RTECS QJ5775000
          Molar mass 174.2
          Chemical formula C₁₀H₆O₃
          Structure formula
          Purity ≥95% by HPLC
          Solubility DMSO (10 mg/ml) or Ethanol (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Special Instructions Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Toxic
          Merck USA index 14, 5269
          References Chao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
          Hennig, L., et al. 1998. Biochemistry 37, 5953.