420120 | Juglone - CAS 481-39-0 - Calbiochem

420120
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₀H₆O₃481-39-0

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      420120-250MG
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          Alu drum 250 mg
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          Description
          OverviewA highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family). Other known PPlase inhibitors such as cyclosporin A, FK506, and rapamycin are not reported to inhibit the parvulin family of PPlases. The inactivation is shown to occur via the addition of thiol groups to juglone and not by any redox process. Exhibits bacteriostatic and fungistatic effects. Reported to be cytotoxic towards eukaryotic cells and to block transcription by RNA polymerase II.
          Catalogue Number420120
          Brand Family Calbiochem®
          Synonyms5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone
          References
          ReferencesChao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
          Hennig, L., et al. 1998. Biochemistry 37, 5953.
          Product Information
          CAS number481-39-0
          ATP CompetitiveN
          FormOrange solid
          Hill FormulaC₁₀H₆O₃
          Chemical formulaC₁₀H₆O₃
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetPPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSQJ5775000
          Safety Information
          R PhraseR: 36/37/38-25

          Irritating to eyes, respiratory system and skin.
          Toxic if swallowed.
          S PhraseS: 45-26

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420120

          References

          Reference overview
          Chao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
          Hennig, L., et al. 1998. Biochemistry 37, 5953.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2008 RFH
          Synonyms5-Hydroxy-1,4-naphthlenedione, 5-Hydroxy-p-naphthoquinone
          DescriptionOriginally isolated from the fruit shells and leaves of walnut trees, juglone is a highly selective, cell permeable, irreversible inhibitor of the parvulin family of peptidyl-prolyl cis/trans isomerases (PPIase). Functions by covalently modifying sulfhydryl groups in the target enzymes. Exhibits bacteriostatic and fungistatic properties as well as cytotoxicity in eukaryotic cells. Also reported to directly block transcription in eukaryotic cells by RNA polymerase I, II, and III as determined by nuclear run-off (IC50 = 7 µM, 7 µM, and 2 µM, respectively). Disrupts formation of functional pre-initiation complexes via modification of sulhydryl groups, but does not significantly affect initiation or elongation. Does not inhibit restriction endonucleases or T7 RNA polymerase.
          FormOrange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number481-39-0
          RTECSQJ5775000
          Chemical formulaC₁₀H₆O₃
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Toxic
          Merck USA index14, 5269
          ReferencesChao, S.H., et al. 2001. Nucleic Acids Res. 29, 767.
          Hennig, L., et al. 1998. Biochemistry 37, 5953.