420345 | Kaempferol - CAS 520-18-3 - Calbiochem

420345
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₅H₁₀O₆520-18-3

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      420345-25MG
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      Discontinued
      There is a newer version of this product
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          25 mg
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          Description
          Overview A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50 = 180 µM), and of transcriptional activation of COX-2 (IC50<15 µM).
          Catalogue Number 420345
          Brand Family Calbiochem®
          Synonyms 3,4ʹ,5,7-Tetrahydroxyflavone
          References
          References Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
          Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
          Wang, H., et al. 2000. Phytomedicine 7, 15.
          Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
          Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
          Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
          Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.
          Product Information
          CAS number 520-18-3
          ATP Competitive N
          Form Yellow solid
          Hill Formula C₁₅H₁₀O₆
          Chemical formula C₁₅H₁₀O₆
          Molar Mass 286.2
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target Topoisomerase I-catalyzed DNA religation in HL-60 cells
          Primary Target IC<sub>50</sub> 180 µM against COX-1 activity
          Purity ≥97% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECS LK9275200
          Safety Information
          R Phrase R: 36/37/38-40

          Irritating to eyes, respiratory system and skin.
          Limited evidence of a carcinogenic effect.
          S Phrase S: 22-26-36

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          420345

          References

          Reference overview
          Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
          Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
          Wang, H., et al. 2000. Phytomedicine 7, 15.
          Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
          Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
          Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
          Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 02-January-2008 JSW
          Synonyms 3,4ʹ,5,7-Tetrahydroxyflavone
          Description A cell-permeable, phytoestrogen that offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Reduces the activation of caspases 2, 3, 8, and 9 by Aβ. Inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Also shown to protect against NMDA-induced neuronal toxicity in vitro in cultured rat cortical neurons. Acts as an inhibitor of cyclooxygenases (COX-1, IC50 = 180 µM) and COX-2 (IC50 = ~15 µM).
          Form Yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 520-18-3
          RTECS LK9275200
          Molar mass 286.2
          Chemical formula C₁₅H₁₀O₆
          Structure formula
          Purity ≥97% by HPLC
          Solubility DMSO (25 mg/ml) or Ethanol (20 mg/ml)
          Storage -20°C
          Protect from light
          No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index 14, 5274
          References Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
          Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
          Wang, H., et al. 2000. Phytomedicine 7, 15.
          Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
          Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
          Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
          Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.