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444143 | MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

444143
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₃₀H₃₀Cl₂N₄O₄548472-68-0

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      444143-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available.
          Catalogue Number444143
          Brand Family Calbiochem®
          SynonymsMDM2 Inhibitor IV
          References
          ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.
          Product Information
          CAS number548472-68-0
          ATP CompetitiveN
          FormSolid
          Hill FormulaC₃₀H₃₀Cl₂N₄O₄
          Chemical formulaC₃₀H₃₀Cl₂N₄O₄
          ReversibleN
          Structure formula Image
          Applications
          Biological Information
          Primary TargetMDM2
          Primary Target IC<sub>50</sub>90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b
          Purity≥98% by TLC and HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444143

          References

          Reference overview
          Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.

          Brochure

          Title
          Interactive Pathway Calendar
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-August-2008 RFH
          SynonymsMDM2 Inhibitor IV
          DescriptionA cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number548472-68-0
          Chemical formulaC₃₀H₃₀Cl₂N₄O₄
          Structure formula
          Purity≥98% by TLC and HPLC
          SolubilityDMSO (25 mg/ml) or Ethanol (25 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.