444143 | MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

444143
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₃₀H₃₀Cl₂N₄O₄548472-68-0

      Pricing & Availability

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      444143-1MG
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          1 mg
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          Description
          Overview A cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available.
          Catalogue Number 444143
          Brand Family Calbiochem®
          Synonyms MDM2 Inhibitor IV
          References
          References Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.
          Product Information
          CAS number 548472-68-0
          ATP Competitive N
          Form Solid
          Hill Formula C₃₀H₃₀Cl₂N₄O₄
          Chemical formula C₃₀H₃₀Cl₂N₄O₄
          Molar Mass 581.5
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target MDM2
          Primary Target IC<sub>50</sub> 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b
          Purity ≥98% by TLC and HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO or EtOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          444143

          References

          Reference overview
          Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.

          Brochure

          Title
          Interactive Pathway Calendar
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 06-August-2008 RFH
          Synonyms MDM2 Inhibitor IV
          Description A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
          Form Solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 548472-68-0
          Molar mass 581.5
          Chemical formula C₃₀H₃₀Cl₂N₄O₄
          Structure formula
          Purity ≥98% by TLC and HPLC
          Solubility DMSO (25 mg/ml) or Ethanol (25 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          References Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.