487928 | Nocodazole - CAS 31430-18-9 - Calbiochem

487928
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₄H₁₁N₃O₃S31430-18-9

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      487928-10MG
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          10 mg
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          Description
          Overview Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).
          Catalogue Number 487928
          Brand Family Calbiochem®
          Synonyms R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
          References
          References Park, H., et al. 2011. Chem. Med. Chem. in press.
          Bunz, F., et al. 1998. Science 282, 1497.
          Fleischman, L.F., et al. 1993. Oncogene 8, 771.
          Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
          Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
          Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
          Product Information
          CAS number 31430-18-9
          Form Pale yellow solid
          Hill Formula C₁₄H₁₁N₃O₃S
          Chemical formula C₁₄H₁₁N₃O₃S
          Molar Mass 301.3
          Structure formula Image
          Applications
          Application Inhibitor of mitosis.
          Biological Information
          Primary Target Promotes tubulin depolymerization
          Purity ≥99% by HPLC
          Physicochemical Information
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECS DD6521000
          Safety Information
          R Phrase R: 40-63

          Limited evidence of a carcinogenic effect.
          Possible risk of harm to the unborn child.
          S Phrase S: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +15°C to +30°C
          Special Instructions Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          487928

          Citations

          Title
        • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 19-June-2012 JSW
          Synonyms R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
          Description Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd < 2 µM).
          Form Pale yellow solid
          CAS number 31430-18-9
          RTECS DD6521000
          Molar mass 301.3
          Chemical formula C₁₄H₁₁N₃O₃S
          Structure formula
          Purity ≥99% by HPLC
          Solubility DMSO (5 mg/ml)
          Storage +15°C to +30°C
          Special Instructions Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
          Toxicity Carcinogenic / Teratogenic
          References Park, H., et al. 2011. Chem. Med. Chem. in press.
          Bunz, F., et al. 1998. Science 282, 1497.
          Fleischman, L.F., et al. 1993. Oncogene 8, 771.
          Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
          Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
          Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
          Citation
        • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.