528116 | PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem

528116
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₆H₁₄N₅O₄SBr • HCl • 2H₂O372196-77-5

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      528116-5MG
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      Discontinued
      There is a newer version of this product
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          Will advise

          5 mg
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          Description
          Overview A cell-permeable imidazopyridine compound that acts as a highly potent and ATP-competitive DNA-PK and p110α-selective PI3-K inhibitor (IC50 = 0.3, 40, 100, and 850 nM for p110α, p110γ, PI 3-K C2β, and p110β, respectively). Shown to effectively block cellular PI3-K/Akt signaling and inhibit tumor growth both in vitro (IC50 ≤58 nM in MCF7, MCF7 ADR-res, HeLa, A375, and A549 cultures) and in mice in vivo (62% inhibition of HeLa xenograft in 2 weeks, 50 mg/kg/day, i.p.).
          Catalogue Number 528116
          Brand Family Calbiochem®
          Synonyms N-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PI 3-K Inhibitor VIII, PIK-75
          References
          References Kim, S., et al. 2007. Blood 110, 4206.
          Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
          Knight, Z.A., et al. 2007. Cell 125, 733.
          Product Information
          CAS number 372196-77-5
          Form Pale yellow solid
          Hill Formula C₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
          Chemical formula C₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
          Molar Mass 524.8
          Hygroscopic Hygroscopic
          Structure formula Image
          Applications
          Biological Information
          Purity ≥95% by HPLC
          Physicochemical Information
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          528116

          References

          Reference overview
          Kim, S., et al. 2007. Blood 110, 4206.
          Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
          Knight, Z.A., et al. 2007. Cell 125, 733.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 13-December-2013 JSW
          Synonyms N-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PI 3-K Inhibitor VIII, PIK-75
          Description A cell-permeable imidazopyridine compound that acts as a highly potent and ATP-competitive DNA-PK and p110α-selective PI3-K inhibitor (IC50 = 0.3, 40, 100, and 850 nM for p110α, p110γ, PI 3-K C2β, and p110β, respectively). Shown to effectively block cellular PI3-K/Akt signaling and inhibit tumor growth both in vitro (IC50 ≤58 nM in MCF7, MCF7 ADR-res, HeLa, A375, and A549 cultures) and in mice in vivo (62% inhibition of HeLa xenograft in 2 weeks, 50 mg/kg/day, i.p.).
          Form Pale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 372196-77-5
          Molar mass 524.8
          Chemical formula C₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
          Structure formula
          Purity ≥95% by HPLC
          Solubility DMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Hygroscopic
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          References Kim, S., et al. 2007. Blood 110, 4206.
          Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
          Knight, Z.A., et al. 2007. Cell 125, 733.