528108 | PI 3-Kγ Inhibitor II - CAS 648449-76-7 - Calbiochem

528108
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₁H₅F₂NO₄S648449-76-7

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      528108-5MG
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      Discontinued
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          5 mg
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          Description
          Overview A cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
          Catalogue Number 528108
          Brand Family Calbiochem®
          Synonyms 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II
          References
          References Bilancio, A., et al. 2006. Blood 107, 642.
          Camps, M., et al. 2005. Nat. Med. 11, 936.
          Product Information
          CAS number 648449-76-7
          ATP Competitive Y
          Form Off-white solid
          Hill Formula C₁₁H₅F₂NO₄S
          Chemical formula C₁₁H₅F₂NO₄S
          Molar Mass 285.2
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target PI 3-Kγ
          Primary Target IC<sub>50</sub> 250 nM against PI 3-Kγ
          Primary Target K<sub>i</sub> 180 nM
          Purity ≥98% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO or EtOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          528108

          References

          Reference overview
          Bilancio, A., et al. 2006. Blood 107, 642.
          Camps, M., et al. 2005. Nat. Med. 11, 936.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 27-March-2008 RFH
          Synonyms 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II
          Description A cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
          Form Off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 648449-76-7
          Molar mass 285.2
          Chemical formula C₁₁H₅F₂NO₄S
          Structure formula
          Purity ≥98% by HPLC
          Solubility DMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          References Bilancio, A., et al. 2006. Blood 107, 642.
          Camps, M., et al. 2005. Nat. Med. 11, 936.