506132 | Pifithrin-α - CAS 63208-82-2 - Calbiochem

506132
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₆H₁₈N₂OS·HBr63208-82-2

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      506132-10MG
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          10 mg
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          506132-5MG
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              5 mg
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              Description
              Overview A cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.
              Catalogue Number 506132
              Brand Family Calbiochem®
              Synonyms 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
              References
              References Murphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
              Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
              Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
              Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
              Ferber, D. 1999. Science 285, 1651.
              Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
              Komarov, P.G., et al. 1999. Science 285, 1733.
              Product Information
              CAS number 63208-82-2
              ATP Competitive N
              Form Off-white solid
              Hill Formula C₁₆H₁₈N₂OS·HBr
              Chemical formula C₁₆H₁₈N₂OS·HBr
              Molar Mass 367.3
              Reversible Y
              Structure formula Image
              Applications
              Biological Information
              Primary Target PS3
              Purity ≥95% by HPLC
              Physicochemical Information
              Cell permeable Y
              Solubility DMSO
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze No
              Special Instructions Following reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              MSDS

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              Certificates of Analysis

              TitleLot Number
              506132

              References

              Reference overview
              Murphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
              Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
              Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
              Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
              Ferber, D. 1999. Science 285, 1651.
              Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
              Komarov, P.G., et al. 1999. Science 285, 1733.

              Brochure

              Title
              p53 And Related Products
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision 03-April-2008 RFH
              Synonyms 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
              Description A reversible inhibitor of p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects mice from lethal genotoxic stress associated with anticancer treatment without promoting tumor formation. Has been reported to protect neurons against β-amyloid and glutamate-induced apoptosis.
              Form Off-white solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number 63208-82-2
              Molar mass 367.3
              Chemical formula C₁₆H₁₈N₂OS·HBr
              Structure formula
              Purity ≥95% by HPLC
              Solubility DMSO (100 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze No
              Special Instructions Following reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
              Toxicity Standard Handling
              References Murphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
              Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
              Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
              Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
              Ferber, D. 1999. Science 285, 1651.
              Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
              Komarov, P.G., et al. 1999. Science 285, 1733.