557514 | Ro-31-8425 - CAS 131848-97-0 - Calbiochem

557514
Price could not be retrieved
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited Availability Limited Availability
Discontinued
There is a newer version of this product
Limited Quantities Available
Availability to be confirmed
      Will advise
      View Pricing & Availability
         CompareClick To Print This Page

      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₂₆H₂₄N₄O₂ · HCl131848-97-0

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      557514-1MG
      Retrieving availability...
      Limited Availability Limited Availability
      Discontinued
      There is a newer version of this product
      Limited Quantities Available
      Availability to be confirmed
          Will advise

          1 mg
          Retrieving price...
          Price could not be retrieved
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          Overview A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε).
          Catalogue Number 557514
          Brand Family Calbiochem®
          Synonyms 2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
          References
          References Merritt, J.E., et al. 1997. Cell Signal 9, 53.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
          Product Information
          CAS number 131848-97-0
          ATP Competitive Y
          Form Reddish-orange solid
          Hill Formula C₂₆H₂₄N₄O₂ · HCl
          Chemical formula C₂₆H₂₄N₄O₂ · HCl
          Molar Mass 461.0
          Reversible Y
          Structure formula Image
          Applications
          Biological Information
          Primary Target PKC
          Primary Target IC<sub>50</sub> 15 nM for rat brain PKC; 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε
          Purity ≥94% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R Phrase R: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S Phrase S: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

          Languages
          Colombia Danmark Deutschland
          Ellas English España
          France Italia Korea
          Magyarország Nederland  Norge
          Polska Portugal Suomi
          Sverige България

          Certificates of Analysis

          TitleLot Number
          557514

          References

          Reference overview
          Merritt, J.E., et al. 1997. Cell Signal 9, 53.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 13-May-2010 JSW
          Synonyms 2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
          Description A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε). Shows slight selectivity for the conventional PKC isozymes PKCα, PKCβ, and PKCγ over the Ca2+-independent PKC isozyme PKCε.
          Form Reddish-orange solid
          CAS number 131848-97-0
          Molar mass 461.0
          Chemical formula C₂₆H₂₄N₄O₂ · HCl
          Structure formula
          Purity ≥94% by HPLC
          Solubility DMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          References Merritt, J.E., et al. 1997. Cell Signal 9, 53.
          Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.