559300 | Safingol - CAS 15639-50-6 - Calbiochem

559300
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₈H₃₉NO₂15639-50-6

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      559300-1MG
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          1 mg
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          Description
          Overview A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 µM and 31 µM, respectively). Inhibits human PKCα, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 µM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis.
          Catalogue Number 559300
          Brand Family Calbiochem®
          Synonyms L-threo-Dihydrosphingosine
          References
          References Kedderis, L.B., et al. 1995. Fundam. Appl. Toxicol. 25, 201.
          Sachs, C.W., et al. 1995. J. Biol. Chem. 270, 26639.
          Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87,1394.
          Product Information
          CAS number 15639-50-6
          Form White solid
          Hill Formula C₁₈H₃₉NO₂
          Chemical formula C₁₈H₃₉NO₂
          Molar Mass 301.5
          Reversible Y
          Structure formula Image
          Applications
          Biological Information
          Primary Target Enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC
          Primary Target IC<sub>50</sub> 37.5 µM and 31 µM, inhibiting enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC, respectively
          Purity ≥98% by TLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO, EtOH, or MeOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R Phrase R: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S Phrase S: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Special Instructions Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          559300

          Brochure

          Title
          Bioactive Lipids Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 11-January-2010 RFH
          Synonyms L-threo-Dihydrosphingosine
          Description A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 µM and 31 µM, respectively). Inhibits human PKCα, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 µM). Enhances the cytotoxic effect of the chemotherapeutic agent mitomycin C (MMC; Cat. No. 47589) in gastric cancer cells by promoting drug-induced apoptosis.
          Form White solid
          CAS number 15639-50-6
          Molar mass 301.5
          Chemical formula C₁₈H₃₉NO₂
          Structure formula
          Purity ≥98% by TLC
          Solubility DMSO (5 mg/ml), ethanol (10 mg/ml), or methanol (5 mg/ml)
          Storage -20°C
          Special Instructions Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          References Kedderis, L.B., et al. 1995. Fundam. Appl. Toxicol. 25, 201.
          Sachs, C.W., et al. 1995. J. Biol. Chem. 270, 26639.
          Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87,1394.