647925 | Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

647925
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      Overview

      Key Spec Table

      Empirical FormulaCAS #
      C₁₇H₂₂N₂O₃58880-19-6

      Pricing & Availability

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      647925-1MG
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          1 mg
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          Description
          Overview A potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. A 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available.
          Catalogue Number 647925
          Brand Family Calbiochem®
          Synonyms 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
          References
          References Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
          Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
          Taunton, J., et al. 1996. Science 272, 408.
          Futamura, M., et al. 1995. Oncogene 10, 1119.
          Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
          Product Information
          CAS number 58880-19-6
          ATP Competitive N
          Form Off-white lyophilized solid
          Hill Formula C₁₇H₂₂N₂O₃
          Chemical formula C₁₇H₂₂N₂O₃
          Molar Mass 302.4
          Reversible Y
          Structure formula Image
          Applications
          Biological Information
          Primary Target histone deactylase
          Primary Target IC<sub>50</sub> 73 nM inhibiting IL-2 gene expressionin Jurkat cells
          Purity ≥98% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO, EtOH, MeOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECS MI5215000
          Safety Information
          R Phrase R: 20/21/22-36/37/38-43

          Harmful by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause sensitization by skin contact.
          S Phrase S: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze No
          Special Instructions Following reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MSDS

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          Certificates of Analysis

          TitleLot Number
          647925

          References

          Reference overview
          Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
          Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
          Taunton, J., et al. 1996. Science 272, 408.
          Futamura, M., et al. 1995. Oncogene 10, 1119.
          Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.

          Citations

          Title
        • Qiou Wei, W. Keith Miskimins and Robin Miskimins. (2005) Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Journal of Biological Chemistry 280, 16284-16294.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 15-September-2008 RFH
          Synonyms 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
          Description A potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model.
          Form Off-white lyophilized solid
          CAS number 58880-19-6
          RTECS MI5215000
          Molar mass 302.4
          Chemical formula C₁₇H₂₂N₂O₃
          Structure formula
          Purity ≥98% by HPLC
          Solubility DMSO (20 mg/ml), ethanol (1 mg/ml), or methanol
          Storage -20°C
          Do Not Freeze No
          Special Instructions Following reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
          Toxicity Harmful
          References Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
          Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
          Taunton, J., et al. 1996. Science 272, 408.
          Futamura, M., et al. 1995. Oncogene 10, 1119.
          Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
          Citation
        • Qiou Wei, W. Keith Miskimins and Robin Miskimins. (2005) Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Journal of Biological Chemistry 280, 16284-16294.