676377 | Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem

676377
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula CAS #
      C₅₄H₉₀N₆O₁₈2001-95-8

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      676377-100MG
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          100 mg
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          676377-25MG
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              25 mg
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              Description
              Overview A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore of the mobile ion-carrier type that transports alkali metal ions across artificial or biological lipid membranes. Induces K+ conductivity in cell membranes at concentrations as low as 10-8 M. Often used in membrane electrode systems for determining K+ concentration. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.
              Catalogue Number 676377
              Brand Family Calbiochem®
              References
              References Harada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
              Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
              Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
              Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
              Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
              Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
              Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
              Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
              Pape, P.C., et al. 1992. J. Physiol. 449, 219.
              Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
              Lerner, A., et al. 1982. FEBS Lett. 146, 9.
              Product Information
              CAS number 2001-95-8
              ATP Competitive N
              Form White crystalline solid
              Hill Formula C₅₄H₉₀N₆O₁₈
              Chemical formula C₅₄H₉₀N₆O₁₈
              Molar Mass 1111.3
              Reversible N
              Structure formula Image
              Applications
              Biological Information
              Primary Target NGF-induced neuronal differentiation
              Purity ≥93% by HPLC
              Physicochemical Information
              Cell permeable N
              Solubility Acetic Acid, Chloroform, DMSO, or Ether
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECS YV9468000
              Safety Information
              R Phrase R: 26/27/28

              Very toxic by inhalation, in contact with skin and if swallowed.
              S Phrase S: 22-36/37/39-45

              Do not breathe dust.
              Wear suitable protective clothing, gloves and eye/face protection.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Highly Toxic
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage +15°C to +30°C
              Do not freeze No
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              MSDS

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              Certificates of Analysis

              TitleLot Number
              676377

              References

              Reference overview
              Harada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
              Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
              Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
              Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
              Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
              Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
              Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
              Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
              Pape, P.C., et al. 1992. J. Physiol. 449, 219.
              Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
              Lerner, A., et al. 1982. FEBS Lett. 146, 9.

              Brochure

              Title
              Ionophores Technical Bulletin
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision 19-May-2008 RFH
              Description A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore that transports alkali metal ions across artificial or biological lipid membranes (Rb+ >K+ >Cs+ >Ag+ >NH4+ >Na+ >Li+). Induces K+ conductivity in cell membranes at concentrations as low as 10 nM. Because of its ability to affect membrane transport of K+ and to create a hydrophobic layer on solid electrodes, it is often used in membrane electrode systems for determining K+ concentration. Useful in studies of K+ transport in mitochondria. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.
              Form White crystalline solid
              CAS number 2001-95-8
              RTECS YV9468000
              Molar mass 1111.3
              Chemical formula C₅₄H₉₀N₆O₁₈
              Structure formula
              Purity ≥93% by HPLC
              Solubility Acetic acid, CHCl₃, DMSO, or ether
              Storage +15°C to +30°C
              Do Not Freeze No
              Toxicity Highly Toxic
              Merck USA index 14, 9910
              References Harada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
              Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
              Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
              Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
              Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
              Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
              Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
              Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
              Pape, P.C., et al. 1992. J. Physiol. 449, 219.
              Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
              Lerner, A., et al. 1982. FEBS Lett. 146, 9.

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              Categories

              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Mitochondrial Function Inhibitors
              Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores