692000 | ZM 336372 - CAS 208260-29-1 - Calbiochem

692000
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₃H₂₃N₃O₃208260-29-1

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      692000-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.
          Catalogue Number692000
          Brand Family Calbiochem®
          SynonymsN-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
          References
          ReferencesHall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.
          Product Information
          CAS number208260-29-1
          ATP CompetitiveY
          DeclarationSold under license of PCT Application W098/22,103.
          FormOff-white solid
          Hill FormulaC₂₃H₂₃N₃O₃
          Chemical formulaC₂₃H₂₃N₃O₃
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetProtein kinase c-Raf
          Primary Target IC<sub>50</sub>70 nM against protein kinase c-Raf
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          692000

          References

          Reference overview
          Hall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.

          Brochure

          Title
          MAP Kinases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-January-2010 RFH
          SynonymsN-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
          DescriptionA potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold greater potency compared to B-Raf. Has no significant effect on many other protein kinases tested (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number208260-29-1
          Chemical formulaC₂₃H₂₃N₃O₃
          Structure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.