Specially Developed for the Separation of Enantiomers

Request Information

Chiral Stationary Phases for HPLCChiral chromatography has become a necessary tool - not only for the analytical determination of enantiomeric purity, but also for the isolation of pure enantiomers. Its importance has particularly grown in the pharmaceutical, chemical, and agricultural industries. The chromatographic enantiomer separation by chiral stationary phase is an efficient and rapid method used in the control of chiral pharmaceuticals or flavor ingredients. The characteristics that make compounds chiral can produce critically different pharmacological effects in biological systems. As a result, the demand for stereoselective separation techniques and analytical assays to evaluate the enantiomeric purity of chiral compounds has increased.

To answer these needs, Merck offers ChiraDex® HPLC top quality columns for enantiomer analysis. Our ChiraDex® stationary phase is a versatile HPLC column characterized by broad enantioselectivity and can be used for the separation of enantiomers of numerous different classes of substances. ChiraDex® is based on beta-cyclodextrin covalently linked to spherical particles of silica, and is well suited for the chiral separation of hydrocarbons, steroids, phenol esters and derivatives, aromatic amines, and heterocycles with a 5-membered ring to 7-membered ring. Simply composed RP-eluents can be used in most separations.

Application Notes Finder
Search for chromatography applications by analyte, column type, detection method, sorbent type or any other search term:
GC Columns

Columns, solvents, standards & CRMs for GC
View our full line of GC products at sigma-aldrich.com

Learn more
HPLC Workflow Solutions - Stationary Phase

HPLC Workflow Solutions

Stationary Phase

Learn More