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For the Sake of Your Protein


Buffer quality is vital for the success of biopharmaceutical processes because they are indispensable in nearly every production step. We offer you a wide range of buffer materials to cover all commonly used buffering systems, such as phosphates, acetates or organic buffers like TRIS, HEPES, MES and our new Imidazole.

In upstream processes, buffers optimize pH and other process parameters in order to obtain the desired product characteristics. In downstream, they help maintaining defined purification conditions to stabilize your valuable proteins while protecting them from unwanted contamination.

Benefits
  • All manufactured to GMP*
  • Multicompendial (in case applicable)
  • Low bioburden and endotoxin levels
  • Low UV-absorbance of aqueous solutions
Full Range of Buffers – For Minimized Risk

In order to ensure reproducible processes, Merck uses only high-purity raw material of defined specifications. Our manufacturing processes have been designed to minimize microbiological contamination and endotoxin concentrations. In addition, most buffers are specified to non-detectable enzymatic activities of DNases, RNases, or proteases. This is what makes these buffers particularly suitable for biochromatography. Qualification kits with samples from three batches are available on request.

EMPROVE® bio – Comprehensive Regulatory Documentation

Most of our buffer products bear the EMPROVE® bio trademark. EMPROVE® products are conceived to make your work even faster and more cost-efficient: they come with comprehensive regulatory documentation that contributes considerably to the quality part of your registration dossier.

PhosphatesAcetatesCitratesTRIS + organicpH adjustment
137039
KH2PO4
137000
HOAc 100%
137002
Citric acid
108307
TRIS High Purity
110165
HCI 1N
137010
K2HPO4
137047
HOAc 30%
137003
Citric acid-H2
108386
TRIS
137031
NaOH 1N 
137036
Na2HPO4
137046
NaOAc 
137042
Na-citrate
108219
TRIS-HCI
137035
HOAc 1N
137017
NaCl
137012
NaOAc-3H2O
  137017
NaCl
 
137018
NaH2PO4
    110110
HEPES
 
137073
MES-Na
137074
MES
NEW
137098
Imidazole

We also offer ready-to-use buffer solutions in disposable bags. For more information please click here.

For more information please contact us.

 

 * based on IPEC - PQG GMP Guide for pharmaceutical excipients 2006.

 
 
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High-throughput Process Development: Utilizing the full potential of miniature chromatography columns

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