182705 | AhR Antagonist - CAS 301326-22-7 - Calbiochem

182705
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      Overview

      Replacement Information

      Tabla espec. clave

      Fórmula empírica Nº CAS
      C₁₉H₁₉N₅O301326-22-7

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      182705-10MG
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          10 mg
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          Descripción
          Visión de conjunto A cell-permeable pyrazolo-amide compound that potently blocks the binding of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) to AhR (aryl hydrocarbon receptor) in a dose-dependent manner. Shown to Inhibit TCDD-induced AhR transcription activity in HepG2 cells in vitro (IC50 = 30 nM) and prevent TCDD-elicited liver toxicity and wasting syndrome in mice in vivo. Unlike the commonly used AhR antagonist flavone, this inhibitor has no effect on estrogen receptor transcription activity, nor does it exhibit TCDD-like agonist activity even at concentrations as high as 10 µM.
          Número de catálogo 182705
          Marca de familia Calbiochem®
          Sinónimos 2-Methyl-2H-pyrazole-3-carboxylic acid-(2-methyl-4-o-tolyl-azophenyl)-amide, CH-223191
          Referencias bibliográficas
          Referencias bibliográficas Kim, S.H., et al. 2006. Mol. Pharmacol. 69, 1871.
          Información del producto
          Número de CAS 301326-22-7
          ATP Competitivo N
          Formulario Orange-brown
          Fórmula Hill C₁₉H₁₉N₅O
          Fórmula química C₁₉H₁₉N₅O
          Molar Mass 333.4
          Reversible N
          Imagen fórmula estructural
          Aplicaciones
          Información biológica
          Objetivo principal AhR (aryl hydrocarbon receptor)
          Objetivo principal IC50 30 nM in blocking TCDD-induced AhR transcription activity in HepG2 cells in vitro
          Pureza ≥95% by HPLC
          Información fisicoquímica
          Permeabilidad celular Y
          Solubilidad DMSO
          Dimensiones
          Información de materiales
          Información toxicológica
          Información de seguridad según el GHS
          Información de seguridad
          Declaraciones de uso del producto
          Información de almacenamiento y transporte
          Código de envío Ambient Temperature Only
          Toxicidad Irritant
          Almacenamiento +2°C to +8°C
          Proteger de la luz Protect from light
          No congelar No
          Instrucciones especiales Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Información sobre embalaje
          Envasado en atmósfera inerte Packaged under inert gas
          Información de transporte
          Información complementaria
          Especificaciones

          Documentation

          Ficha datos de seguridad (MSDS)

          Idiomas
          Argentina Australia Belgie
          Belgien Belgique Brasil
          Canadian English Canadian-French Ceská Rep
          Chile China Colombia
          Cyprus Danmark Deutschland
          Eesti Ellas English
          España France Hrvatska 
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          Lietuva Magyarország Malta
          México Nederland  Norge
          Peru Polska Portugal
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          Srpski Standard EU English Suisse
          Suomi Sverige Svizzera
          Taiwan Thailand Türkiye
          US English United Kingdom Éire
          Österreich България Россия

          Certificados de análisis

          CargoNúmero de lote
          182705

          Referencias bibliográficas

          Visión general referencias
          Kim, S.H., et al. 2006. Mol. Pharmacol. 69, 1871.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revisión 05-April-2011 RFH
          Sinónimos 2-Methyl-2H-pyrazole-3-carboxylic acid-(2-methyl-4-o-tolyl-azophenyl)-amide, CH-223191
          Descripción A cell-permeable pyrazolo-amide compound that potently blocks the binding of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) to AhR (aryl hydrocarbon receptor) in a dose-dependent manner. Shown to Inhibit TCDD-induced AhR transcription activity in HepG2 cells in vitro (IC50 = 30 nM) and prevent TCDD-elicited liver toxicity and wasting syndrome in mice in vivo. Unlike the commonly used AhR antagonist flavone, this inhibitor has no effect on estrogen receptor transcription activity, nor does it exhibit TCDD-like agonist activity even at concentrations as high as 10 µM.
          Formulario Orange-brown
          Gas inerte (Sí/No) Packaged under inert gas
          Número de CAS 301326-22-7
          Masa molar 333.4
          Fórmula química C₁₉H₁₉N₅O
          Fórmula estructural
          Pureza ≥95% by HPLC
          Solubilidad DMSO (10 mg/ml)
          Almacenamiento +2°C to +8°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicidad Irritant
          Referencias bibliográficas Kim, S.H., et al. 2006. Mol. Pharmacol. 69, 1871.