239764 | Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

239764
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      Overview

      Replacement Information

      Tabla espec. clave

      Fórmula empírica Nº CAS
      C₁₅H₂₃NO₄66-81-9

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      239764-100MG
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          100 mg
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          239764-1GM
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              1 gm
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              Descripción
              Visión de conjunto Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions. Also available as a 300 mM solution in DMSO (Cat. No. 508739).
              Número de catálogo 239764
              Marca de familia Calbiochem®
              Referencias bibliográficas
              Referencias bibliográficas Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.
              Información del producto
              Número de CAS 66-81-9
              Formulario White solid
              Fórmula Hill C₁₅H₂₃NO₄
              Fórmula química C₁₅H₂₃NO₄
              Molar Mass 281.3
              Imagen fórmula estructural
              Aplicaciones
              Información biológica
              Objetivo principal hFKBP12
              Objetivo principal K50 3.4 µM
              Pureza ≥98% by HPLC
              Información fisicoquímica
              Solubilidad EtOH or MeOH
              Dimensiones
              Información de materiales
              Información toxicológica
              Información de seguridad según el GHS
              RTECS MA4375000
              Información de seguridad
              Frase R R: 28-40-51/53-61




              Frase S S: 45-53-61



              Declaraciones de uso del producto
              Información de almacenamiento y transporte
              Código de envío Ambient Temperature Only
              Toxicidad Highly Toxic & Carcinogenic / Teratogenic
              Advertencia de materiales peligrosos: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Almacenamiento +15°C to +30°C
              No congelar No
              Instrucciones especiales Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
              Información sobre embalaje
              Información de transporte
              Información complementaria
              Especificaciones

              Documentation

              Ficha datos de seguridad (MSDS)

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              Certificados de análisis

              CargoNúmero de lote
              239764

              Referencias bibliográficas

              Visión general referencias
              Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.

              Folleto

              Cargo
              Tools and Tips for Analyzing Apoptosis

              Citas

              Título
            • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
            • Ficha técnica

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revisión 29-April-2008 RFH
              Descripción Antifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
              Formulario White solid
              Número de CAS 66-81-9
              RTECS MA4375000
              Masa molar 281.3
              Fórmula química C₁₅H₂₃NO₄
              Fórmula estructural
              Pureza ≥98% by HPLC
              Solubilidad Chloroform, Ethanol, and Methanol
              Almacenamiento +15°C to +30°C
              Do Not Freeze No
              Special Instructions Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
              Toxicidad Highly Toxic & Carcinogenic / Teratogenic
              Índice Merck EE.UU. 14, 2728
              Referencias bibliográficas Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
              Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
              Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
              Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
              Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
              Waring, P. 1990. J. Biol. Chem. 265, 14476.
              Cita
            • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.