324693 | Emetine, Dihydrochloride - CAS 316-42-7 - Calbiochem

324693
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      Fórmula empírica Nº CAS
      C₂₉H₄₀N₂O₄ · 2HCl316-42-7

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      324693-250MG
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          250 mg
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          Descripción
          Visión de conjunto Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
          Número de catálogo 324693
          Marca de familia Calbiochem®
          Sinónimos 6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
          Referencias bibliográficas
          Referencias bibliográficas Kong, H.S., et al. 2010. Mol. Pharmacol. in press.
          Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
          Kokuho, T., et al. 1995. Immunobiology 193, 42.
          Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
          Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
          Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
          Landis, R.C., et al. 1991. J. Immunol. 146, 128.
          Schweighoffer, T., et al. 1991. Histochemistry 96, 93.
          Información del producto
          Número de CAS 316-42-7
          ATP Competitivo N
          Formulario White solid with a faint yellow cast
          Fórmula Hill C₂₉H₄₀N₂O₄ · 2HCl
          Fórmula química C₂₉H₄₀N₂O₄ · 2HCl
          Molar Mass 553.6
          Higroscópico Hygroscopic
          Reversible N
          Imagen fórmula estructural
          Aplicaciones
          Información biológica
          Objetivo principal Movement of ribosomes along the mRNA
          Objetivo principal IC50 ≤1 µM as a specific inhibitor of HIF-2α protein stability and transcriptional activity
          Pureza ≥98% by HPLC and Titration (dried basis) (perchloric acid method)
          Información fisicoquímica
          Permeabilidad celular N
          Solubilidad EtOH or H₂O
          Dimensiones
          Información de materiales
          Información toxicológica
          Información de seguridad según el GHS
          RTECS JY5250000
          Información de seguridad
          Frase R R: 28-36/38


          Frase S S: 28-36/37-45



          Declaraciones de uso del producto
          Información de almacenamiento y transporte
          Código de envío Ambient Temperature Only
          Toxicidad Highly Toxic
          Advertencia de materiales peligrosos: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Almacenamiento +2°C to +8°C
          Proteger de la luz Protect from light
          Higroscópico Hygroscopic
          No congelar No
          Instrucciones especiales Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Información sobre embalaje
          Información de transporte
          Información complementaria
          Especificaciones

          Documentation

          Ficha datos de seguridad (MSDS)

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          Certificados de análisis

          CargoNúmero de lote
          324693

          Referencias bibliográficas

          Visión general referencias
          Kong, H.S., et al. 2010. Mol. Pharmacol. in press.
          Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
          Kokuho, T., et al. 1995. Immunobiology 193, 42.
          Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
          Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
          Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
          Landis, R.C., et al. 1991. J. Immunol. 146, 128.
          Schweighoffer, T., et al. 1991. Histochemistry 96, 93.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revisión 20-September-2010 JSW
          Sinónimos 6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
          Descripción Principle alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
          Formulario White solid with a faint yellow cast
          Número de CAS 316-42-7
          RTECS JY5250000
          Masa molar 553.6
          Fórmula química C₂₉H₄₀N₂O₄ · 2HCl
          Fórmula estructural
          Pureza ≥98% by HPLC and Titration (dried basis) (perchloric acid method)
          Solubilidad Ethanol or H₂O (20 mg/ml)
          Almacenamiento +2°C to +8°C
          Protect from light
          Hygroscopic
          Do Not Freeze No
          Special Instructions Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicidad Highly Toxic
          Índice Merck EE.UU. 14, 3559
          Referencias bibliográficas Kong, H.S., et al. 2010. Mol. Pharmacol. in press.
          Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
          Kokuho, T., et al. 1995. Immunobiology 193, 42.
          Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
          Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
          Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
          Landis, R.C., et al. 1991. J. Immunol. 146, 128.
          Schweighoffer, T., et al. 1991. Histochemistry 96, 93.