444143 | MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

444143
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      Overview

      Tabla espec. clave

      Empirical Formula CAS #

      Precios y disponibilidad

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      444143-1MG
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          Description
          Overview A cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available.
          Catalogue Number
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          Synonyms MDM2 Inhibitor IV
          References
          References Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.
          Product Information
          CAS number
          ATP Competitive
          Form Solid
          Hill Formula
          Chemical formula
          Molar Mass 581.5
          Reversible
          Structure formula Image
          Applications
          Biological Information
          Primary Target MDM2
          Primary Target IC50 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b
          Purity ≥98% by TLC and HPLC
          Physicochemical Information
          Cell permeable
          Solubility DMSO or EtOH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
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          Special Instructions Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
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          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ficha datos de seguridad (MSDS)

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          Certificados de análisis

          CargoNúmero de lote
          444143

          Referencias bibliográficas

          Visión general referencias
          Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.

          Folleto

          Cargo
          Interactive Pathway Calendar
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 06-August-2008 RFH
          Synonyms MDM2 Inhibitor IV
          Description A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
          Form Solid
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          Pagelet <null> no encontrado.
          CAS number
          Molar mass 581.5
          Chemical formula
          Structure formula
          Purity ≥98% by TLC and HPLC
          Solubility DMSO (25 mg/ml) or Ethanol (25 mg/ml)
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          Special Instructions Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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          References Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
          Vassilev, L.T., et al. 2004. Science 303, 844.