521275 | PDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem

521275
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      Overview

      Replacement Information

      Tabla espec. clave

      Fórmula empírica Nº CAS
      C₁₀H₄N₆O331253-86-2

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      521275-5MG
      Comprobando disponibilidad...
      Disponibilidad a confirmar Disponibilidad a confirmar
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        Remaining : Will advise
          Se avisará

          5 mg
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          Descripción
          Visión de conjunto A cell-permeable compound that selectively induces apoptosis in AML (Acute Myelogenous Leukemia) with little effect on normal CD34+ AML progenitor cells. Shown to directly inhibit both PDK1 and Akt activities in in vitro kinase assays in a dose-dependent manner and block cellular phosphorylation of Akt at both Ser473 and Thr308. The dual inhibition nature against both PDK1/Akt and Flt3/PIM signaling pathways allows effective killing of AML cells (Average IC50 = 1.05, 1.91, and 0.43 µM for AML with wild-type Flt3, single mutant ITD/D835, and double mutant Flt3-ITD-TDK, respectively) that are otherwise resistant to inhibitors that target only the PDK1/Akt pathway.
          CAS. Nos. 331253-86-2 and 329710-24-9 (two isomers)
          Número de catálogo 521275
          Marca de familia Calbiochem®
          Sinónimos 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one & 10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one, Akt Inhibitor XXI, PDK1 Inhibitor I, KP372-1
          Referencias bibliográficas
          Referencias bibliográficas Zeng, Z., et al. 2006. Cancer Res. 66, 3737.
          Koul, D., et al. 2006. Mol. Cancer Ther. 5, 637.
          Mandal. M., et al. 2006. Oral Oncol. 42, 430.
          Mandal. M., et al. 2005. Br. J. Cancer 92, 1899.
          Información del producto
          Número de CAS 331253-86-2
          ATP Competitivo N
          Formulario Yellow solid
          Fórmula Hill C₁₀H₄N₆O
          Fórmula química C₁₀H₄N₆O
          Molar Mass 224.2
          Reversible N
          Imagen fórmula estructural
          Aplicaciones
          Información biológica
          Objetivo principal Both PDK1 and Akt activities
          Objetivo principal IC50 1.05, 1.91, and 0.43 µM for AML with wild-type Flt3, single mutant ITD/D835, and double mutant Flt3-ITD-TDK, respectively
          Pureza ≥98% by HPLC (sum of two isomers)
          Información fisicoquímica
          Permeabilidad celular Y
          Solubilidad DMSO
          Dimensiones
          Información de materiales
          Información toxicológica
          Información de seguridad según el GHS
          Información de seguridad
          Frase R R: 36/37/38

          Frase S S: 26-36


          Declaraciones de uso del producto
          Información de almacenamiento y transporte
          Código de envío Ambient Temperature Only
          Toxicidad Irritant
          Almacenamiento +2°C to +8°C
          Proteger de la luz Protect from light
          No congelar No
          Instrucciones especiales Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Información sobre embalaje
          Envasado en atmósfera inerte Packaged under inert gas
          Información de transporte
          Información complementaria
          Especificaciones

          Documentation

          Ficha datos de seguridad (MSDS)

          Idiomas
          Australia Canadian English Canadian-French
          Colombia Danmark Deutschland
          Ellas English España
          France Italia Korea
          Magyarország Nederland  Norge
          Polska Portugal Suomi
          Sverige US Español Österreich
          България

          Certificados de análisis

          CargoNúmero de lote
          521275

          Referencias bibliográficas

          Visión general referencias
          Zeng, Z., et al. 2006. Cancer Res. 66, 3737.
          Koul, D., et al. 2006. Mol. Cancer Ther. 5, 637.
          Mandal. M., et al. 2006. Oral Oncol. 42, 430.
          Mandal. M., et al. 2005. Br. J. Cancer 92, 1899.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revisión 18-April-2011 RFH
          Sinónimos 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one & 10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one, Akt Inhibitor XXI, PDK1 Inhibitor I, KP372-1
          Descripción A cell-permeable compound that selectively induces apoptosis in AML (Acute Myelogenous Leukemia) with little effect on normal CD34+ AML progenitor cells. Shown to directly inhibit both PDK1 and Akt activities in in vitro kinase assays in a dose-dependent manner and block cellular phosphorylation of Akt at both Ser473 and Thr308. The dual inhibition nature against both PDK1/Akt and Flt3/PIM signaling pathways allows effective killing of AML cells (Average IC50 = 1.05, 1.91, and 0.43 µM for AML with wild-type Flt3, single mutant ITD/D835, and double mutant Flt3-ITD-TDK, respectively) that are otherwise resistant to inhibitors that target only the PDK1/Akt pathway. CAS. No. 331253-86-2 and 329710-24-9.
          Formulario Yellow solid
          Gas inerte (Sí/No) Packaged under inert gas
          Número de CAS 331253-86-2
          Masa molar 224.2
          Fórmula química C₁₀H₄N₆O
          Fórmula estructural
          Pureza ≥98% by HPLC (sum of two isomers)
          Solubilidad DMSO (10 mg/ml)
          Almacenamiento +2°C to +8°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicidad Irritant
          Referencias bibliográficas Zeng, Z., et al. 2006. Cancer Res. 66, 3737.
          Koul, D., et al. 2006. Mol. Cancer Ther. 5, 637.
          Mandal. M., et al. 2006. Oral Oncol. 42, 430.
          Mandal. M., et al. 2005. Br. J. Cancer 92, 1899.