554726 | REV-ERB Agonist II, SR9009 - Calbiochem

554726
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      Overview

      Replacement Information

      Tabla espec. clave

      Fórmula empírica
      C₂₀H₂₄ClN₃O₄S

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      554726-25MG
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      Debe confirmarse disponibilidad
        Remaining : Will advise
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          25 mg
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          Descripción
          Visión de conjunto A pyrrolidinecarbamate compound that acts as a specific REV-ERB-α/β agonist. Exhibits a direct and reversible binding (Kd = 800 nM REV-ERB-α) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800 nM in Gal4-REV-ERB-α and β transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710 nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100 mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern.
          Número de catálogo 554726
          Marca de familia Calbiochem®
          Sinónimos Ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate
          Referencias bibliográficas
          Referencias bibliográficas Solt, L.A., et al. 2012. Nature 485, 62.
          Información del producto
          Formulario Dark brown liquid
          Fórmula Hill C₂₀H₂₄ClN₃O₄S
          Molar Mass 437.9
          Reversible Y
          Imagen fórmula estructural
          Aplicaciones
          Información biológica
          Objetivo principal REV-ERB-α/&beta
          Pureza ≥96% by HPLC
          Información fisicoquímica
          Permeabilidad celular Y
          Solubilidad DMSO
          Dimensiones
          Información de materiales
          Información toxicológica
          Información de seguridad según el GHS
          Información de seguridad
          Declaraciones de uso del producto
          Información de almacenamiento y transporte
          Código de envío Ambient Temperature Only
          Toxicidad Standard Handling
          Almacenamiento +2°C to +8°C
          Proteger de la luz Protect from light
          No congelar No
          Instrucciones especiales Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Información sobre embalaje
          Envasado en atmósfera inerte Packaged under inert gas
          Información de transporte
          Información complementaria
          Especificaciones

          Documentation

          Ficha datos de seguridad (MSDS)

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          Certificados de análisis

          CargoNúmero de lote
          554726

          Referencias bibliográficas

          Visión general referencias
          Solt, L.A., et al. 2012. Nature 485, 62.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revisión 16-November-2012 JSW
          Sinónimos Ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate
          Descripción A pyrrolidinecarbamate compound that acts as a specific REV-ERB-α/β agonist. Exhibits a direct and reversible binding (Kd = 800 nM REV-ERB-α) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800 nM in Gal4-REV-ERB-α and β transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710 nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100 mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern.
          Formulario Dark brown liquid
          Gas inerte (Sí/No) Packaged under inert gas
          Masa molar 437.9
          Fórmula estructural
          Pureza ≥96% by HPLC
          Solubilidad DMSO (50 mg/ml)
          Almacenamiento +2°C to +8°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicidad Standard Handling
          Referencias bibliográficas Solt, L.A., et al. 2012. Nature 485, 62.