647925 | Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

647925
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      Fórmula empírica Nº CAS
      C₁₇H₂₂N₂O₃58880-19-6

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      647925-1MG
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          Descripción
          Visión de conjunto A potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. A 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available.
          Número de catálogo 647925
          Marca de familia Calbiochem®
          Sinónimos 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
          Referencias bibliográficas
          Referencias bibliográficas Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
          Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
          Taunton, J., et al. 1996. Science 272, 408.
          Futamura, M., et al. 1995. Oncogene 10, 1119.
          Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
          Información del producto
          Número de CAS 58880-19-6
          ATP Competitivo N
          Formulario Off-white lyophilized solid
          Fórmula Hill C₁₇H₂₂N₂O₃
          Fórmula química C₁₇H₂₂N₂O₃
          Molar Mass 302.4
          Reversible Y
          Imagen fórmula estructural
          Aplicaciones
          Información biológica
          Objetivo principal histone deactylase
          Objetivo principal IC50 73 nM inhibiting IL-2 gene expressionin Jurkat cells
          Pureza ≥98% by HPLC
          Información fisicoquímica
          Permeabilidad celular Y
          Solubilidad DMSO, EtOH, MeOH
          Dimensiones
          Información de materiales
          Información toxicológica
          Información de seguridad según el GHS
          RTECS MI5215000
          Información de seguridad
          Frase R R: 20/21/22-36/37/38-43



          Frase S S: 26-36


          Declaraciones de uso del producto
          Información de almacenamiento y transporte
          Código de envío Ambient Temperature Only
          Toxicidad Harmful
          Almacenamiento -20°C
          No congelar No
          Instrucciones especiales Following reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
          Información sobre embalaje
          Información de transporte
          Información complementaria
          Especificaciones

          Documentation

          Ficha datos de seguridad (MSDS)

          Idiomas
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          Portugal Suomi Sverige
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          България

          Certificados de análisis

          CargoNúmero de lote
          647925

          Referencias bibliográficas

          Visión general referencias
          Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
          Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
          Taunton, J., et al. 1996. Science 272, 408.
          Futamura, M., et al. 1995. Oncogene 10, 1119.
          Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.

          Licencias necesarias e Información técnica

          Cargo
          White Paper - The Message in the Marks: Deciphering Cancer Epigenetics

          Citas

          Título
        • Qiou Wei, W. Keith Miskimins and Robin Miskimins. (2005) Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Journal of Biological Chemistry 280, 16284-16294.
        • Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revisión 15-September-2008 RFH
          Sinónimos 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
          Descripción A potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model.
          Formulario Off-white lyophilized solid
          Número de CAS 58880-19-6
          RTECS MI5215000
          Masa molar 302.4
          Fórmula química C₁₇H₂₂N₂O₃
          Fórmula estructural
          Pureza ≥98% by HPLC
          Solubilidad DMSO (20 mg/ml), ethanol (1 mg/ml), or methanol
          Almacenamiento -20°C
          Do Not Freeze No
          Special Instructions Following reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
          Toxicidad Harmful
          Referencias bibliográficas Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
          Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
          Taunton, J., et al. 1996. Science 272, 408.
          Futamura, M., et al. 1995. Oncogene 10, 1119.
          Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
          Cita
        • Qiou Wei, W. Keith Miskimins and Robin Miskimins. (2005) Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Journal of Biological Chemistry 280, 16284-16294.