676377 | Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem

676377
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      Overview

      Tabla espec. clave

      Empirical Formula CAS #

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      676377-100MG
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          100 mg
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          676377-25MG
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              25 mg
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              Description
              Overview A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore of the mobile ion-carrier type that transports alkali metal ions across artificial or biological lipid membranes. Induces K+ conductivity in cell membranes at concentrations as low as 10-8 M. Often used in membrane electrode systems for determining K+ concentration. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.
              Catalogue Number
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              References
              References Harada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
              Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
              Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
              Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
              Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
              Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
              Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
              Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
              Pape, P.C., et al. 1992. J. Physiol. 449, 219.
              Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
              Lerner, A., et al. 1982. FEBS Lett. 146, 9.
              Product Information
              CAS number
              ATP Competitive
              Form White crystalline solid
              Hill Formula
              Chemical formula
              Molar Mass 1111.3
              Reversible
              Structure formula Image
              Applications
              Biological Information
              Primary Target NGF-induced neuronal differentiation
              Purity ≥93% by HPLC
              Physicochemical Information
              Cell permeable
              Solubility Acetic Acid, Chloroform, DMSO, or Ether
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECS
              Safety Information
              R Phrase R: 26/27/28

              Very toxic by inhalation, in contact with skin and if swallowed.
              S Phrase S: 22-36/37/39-45

              Do not breathe dust.
              Wear suitable protective clothing, gloves and eye/face protection.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
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              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Ficha datos de seguridad (MSDS)

              Idiomas
              Australia Canadian English Canadian-French
              Ceská Rep Colombia Danmark
              Deutschland Ellas English
              España España France
              Italia Korea Korea
              Latvija Lietuva Magyarország
              Magyarország Nederland  Norge
              Polska Portugal Suomi
              Sverige Sverige US English
              United Kingdom Österreich България

              Certificados de análisis

              CargoNúmero de lote
              676377

              Referencias bibliográficas

              Visión general referencias
              Harada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
              Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
              Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
              Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
              Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
              Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
              Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
              Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
              Pape, P.C., et al. 1992. J. Physiol. 449, 219.
              Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
              Lerner, A., et al. 1982. FEBS Lett. 146, 9.

              Folleto

              Cargo
              Ionophores Technical Bulletin
              Ficha técnica

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision 19-May-2008 RFH
              Description A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore that transports alkali metal ions across artificial or biological lipid membranes (Rb+ >K+ >Cs+ >Ag+ >NH4+ >Na+ >Li+). Induces K+ conductivity in cell membranes at concentrations as low as 10 nM. Because of its ability to affect membrane transport of K+ and to create a hydrophobic layer on solid electrodes, it is often used in membrane electrode systems for determining K+ concentration. Useful in studies of K+ transport in mitochondria. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.
              Form White crystalline solid
              CAS number
              RTECS
              Molar mass 1111.3
              Chemical formula
              Structure formula
              Purity ≥93% by HPLC
              Solubility Acetic acid, CHCl₃, DMSO, or ether
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              Pagelet <feature_storage_value-> no encontrado.
              Error configuración datos. Pagelet <feature_clustercode_toxicity-> no encontrado.
              Pagelet <feature_storage_value-> no encontrado.
              Merck USA index
              References Harada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
              Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
              Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
              Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
              Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
              Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
              Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
              Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
              Pape, P.C., et al. 1992. J. Physiol. 449, 219.
              Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
              Lerner, A., et al. 1982. FEBS Lett. 146, 9.

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              Categorías

              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Mitochondrial Function Inhibitors
              Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores