688000 | Y-27632 - CAS 146986-50-7 - Calbiochem

688000
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      Fórmula empírica Nº CAS
      C₁₄H₂₁N₃O · 2HCl · H₂O146986-50-7

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      688000-100MG
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          100 mg
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          688000-10MG
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              10 mg
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              688000-1MG
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                  1 mg
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                  688000-5MG
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                      5 mg
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                      Descripción
                      Visión de conjunto A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. Pretreatment with Y-27632 reduces the risk of lung injury in rat models of sepsis. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O and a 10 mM solution in DMSO (Cat. No. 688002) are also available.
                      Número de catálogo 688000
                      Marca de familia Calbiochem®
                      Sinónimos ROCK Inhibitor, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
                      Referencias bibliográficas
                      Referencias bibliográficas Cinel, I., et al. 2012. J. Thorac . Dis. 4, 30.
                      Watanabe, K., et al. 2007. Nature Biotech. 25, 681.
                      Chitaley, K., et al. 2001. Nat. Med. 7, 119.
                      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
                      Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
                      Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
                      Maekawa, M., et al. 1999. Science 285, 895.
                      Uehata, M., et al. 1997. Nature 389, 990.
                      Información del producto
                      Número de CAS 146986-50-7
                      ATP Competitivo Y
                      Declaración Sold under license of PCT Application W098/06,433A1 and under license from Mitsubishi Pharma Tanabe Corporation.
                      Formulario White solid
                      Fórmula Hill C₁₄H₂₁N₃O · 2HCl · H₂O
                      Fórmula química C₁₄H₂₁N₃O · 2HCl · H₂O
                      Molar Mass 338.3
                      Higroscópico Hygroscopic
                      Reversible Y
                      Imagen fórmula estructural
                      Aplicaciones
                      Información biológica
                      Objetivo principal p160 Rho-associated protein kinases (ROCK)
                      Objetivo principal K50 140 nM for p160 Rho-associated protein kinases (ROCK)
                      Pureza ≥95% by HPLC
                      Información fisicoquímica
                      Permeabilidad celular Y
                      Solubilidad H₂O
                      Dimensiones
                      Información de materiales
                      Información toxicológica
                      Información de seguridad según el GHS
                      Información de seguridad
                      Frase R R: 20/21/22

                      Frase S S: 36

                      Declaraciones de uso del producto
                      Información de almacenamiento y transporte
                      Código de envío Ambient Temperature Only
                      Toxicidad Harmful
                      Almacenamiento -20°C
                      Proteger de la luz Protect from light
                      Higroscópico Hygroscopic
                      No congelar No
                      Instrucciones especiales Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
                      Información sobre embalaje
                      Envasado en atmósfera inerte Packaged under inert gas
                      Información de transporte
                      Información complementaria
                      Especificaciones

                      Documentation

                      Ficha datos de seguridad (MSDS)

                      Idiomas
                      Argentina Australia Belgie
                      Belgien Belgique Brasil
                      Canadian English Canadian-French Ceská Rep
                      Chile China Colombia
                      Cyprus Danmark Deutschland
                      Eesti Ellas English
                      España France Hrvatska 
                      Iceland India Indonesia
                      Italia Korea Latvija
                      Lietuva Magyarország Malta
                      México Nederland  Norge
                      Peru Polska Portugal
                      Schweiz Slovenija Slovensko
                      South Africa Srpski Standard EU English
                      Suisse Suomi Sverige
                      Svizzera Taiwan Thailand
                      Türkiye US English US Español
                      United Kingdom Venezuela Vietnamese
                      Éire Österreich България
                      Россия

                      Certificados de análisis

                      CargoNúmero de lote
                      688000

                      Referencias bibliográficas

                      Visión general referencias
                      Cinel, I., et al. 2012. J. Thorac . Dis. 4, 30.
                      Watanabe, K., et al. 2007. Nature Biotech. 25, 681.
                      Chitaley, K., et al. 2001. Nat. Med. 7, 119.
                      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
                      Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
                      Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
                      Maekawa, M., et al. 1999. Science 285, 895.
                      Uehata, M., et al. 1997. Nature 389, 990.

                      Citas

                      Título
                    • Cinel, I., et al. 2012. J. Thorac . Dis. 4, 30.
                    • Jennifer L. Farmer, et al. (2008) Galectin 15 (LGALS15) functions in trophectoderm migration and attachment. Federation of American Societies for Experimental Biology Journal 22, 548-560.
                    • James J. Fiordalisi, Patricia J. Keller and Adrienne D. Cox. (2006) PRL Tyrosine Phosphatases Regulate Rho Family GTPases to Promote Invasion and Motility. Cancer Research 66, 3153-3161.
                    • Karen E. Porter, et al. (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovascular Research 61, 745-755.
                    • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
                    • Ficha técnica

                      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                      Revisión 27-February-2012 RFH
                      Sinónimos ROCK Inhibitor, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
                      Descripción A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinase (Ki = 140 nM for p160ROCK (ROCK-I). Also inhibits ROCK-II with almost equal potency. Inhibition is achieved by competing with ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at high concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contractions (IC50 = 700 nM for phenylephrine-induced contractions in aortic strips). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. Pretreatment with Y-27632 reduces the risk of lung injury in rat models of sepsis.
                      Formulario White solid
                      Gas inerte (Sí/No) Packaged under inert gas
                      Número de CAS 146986-50-7
                      Masa molar 338.3
                      Fórmula química C₁₄H₂₁N₃O · 2HCl · H₂O
                      Fórmula estructural
                      Pureza ≥95% by HPLC
                      Solubilidad H₂O (100 mg/ml)
                      Almacenamiento -20°C
                      Protect from light
                      Hygroscopic
                      Do Not Freeze No
                      Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
                      Toxicidad Harmful
                      Referencias bibliográficas Cinel, I., et al. 2012. J. Thorac . Dis. 4, 30.
                      Watanabe, K., et al. 2007. Nature Biotech. 25, 681.
                      Chitaley, K., et al. 2001. Nat. Med. 7, 119.
                      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
                      Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
                      Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
                      Maekawa, M., et al. 1999. Science 285, 895.
                      Uehata, M., et al. 1997. Nature 389, 990.
                      Cita
                    • Cinel, I., et al. 2012. J. Thorac . Dis. 4, 30.
                    • Jennifer L. Farmer, et al. (2008) Galectin 15 (LGALS15) functions in trophectoderm migration and attachment. Federation of American Societies for Experimental Biology Journal 22, 548-560.
                    • James J. Fiordalisi, Patricia J. Keller and Adrienne D. Cox. (2006) PRL Tyrosine Phosphatases Regulate Rho Family GTPases to Promote Invasion and Motility. Cancer Research 66, 3153-3161.
                    • Karen E. Porter, et al. (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovascular Research 61, 745-755.
                    • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.