207001 | Calcineurin Autoinhibitory Peptide, Cell-permeable - Calbiochem

207001
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      Overview

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₁₃₇H₂₅₁N₇₁O₃₄S₂

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      207001-1MG
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      Disponibilité limitéeDisponibilité limitée
      En stock
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Remaining : Will advise
          Nous vous tiendrons informé

          1 mg
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          Description
          Overview A cell-permeable peptide that is composed of the calcineurin (CaN) autoinhibitory domain (AID) fused to a poly-arginine-based protein transduction domain (11R) and acts as an inhibitor of CaN phosphatase activity. Blocks CaN-dependent NFAT nuclear translocation and NFAT promoter activity in neurons. Protects neuronal cells from glutamate-induced cell death.
          Catalogue Number 207001
          Brand Family Calbiochem®
          Synonyms 11R-CaN-AID, Ac-RRRRRRRRRRRGGGRMAPPRRDAMPSDA-NH₂
          References
          References Terada, H., et al. 2003. J. Neurochem. 87, 1145.
          Product Information
          ATP Competitive N
          Form White lyophilized solid
          Formulation Supplied as a trifluoroacetate salt.
          Hill Formula C₁₃₇H₂₅₁N₇₁O₃₄S₂
          Chemical formula C₁₃₇H₂₅₁N₇₁O₃₄S₂
          Molar Mass 3501.1
          Hygroscopic Hygroscopic
          Peptide Sequence Ac-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Arg-Met-Ala-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-Ser-Asp-Ala-NH₂
          Reversible N
          Applications
          Biological Information
          Primary Target Blocks CaN-dependent NFAT nuclear translocation
          Purity ≥98% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility H₂O
          Peptide Sequence Ac-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Arg-Met-Ala-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-Ser-Asp-Ala-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze No
          Special Instructions Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FDS

          Title

          Material Safety Data Sheet (MSDS)  

          Certificats d'analyse

          TitreNuméro de lot
          207001

          Références bibliographiques

          Aperçu de la référence bibliographique
          Terada, H., et al. 2003. J. Neurochem. 87, 1145.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 27-May-2008 RFH
          Synonyms 11R-CaN-AID, Ac-RRRRRRRRRRRGGGRMAPPRRDAMPSDA-NH₂
          Description A cell-permeable peptide that consists of the calcineurin (CaN) autoinhibitory domain (AID) fused to a poly-arginine-based protein transduction doamin (11R) and acts as an inhibitor of CaN phosphatase activity. Reported to block CaN-dependent NFAT nuclear translocation and NFAT promoter activity in neurons. Also reported to protect neuronal cells from glutamate-induced cell death.
          Form White lyophilized solid
          Formulation Supplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Molar mass 3501.1
          Chemical formula C₁₃₇H₂₅₁N₇₁O₃₄S₂
          Peptide Sequence Ac-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Arg-Met-Ala-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-Ser-Asp-Ala-NH₂
          Purity ≥98% by HPLC
          Solubility H₂O (1 mg/ml)
          Storage -20°C
          Protect from light
          Hygroscopic
          Do Not Freeze No
          Special Instructions Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          References Terada, H., et al. 2003. J. Neurochem. 87, 1145.