440202 | LY 294002 - CAS 154447-36-6 - Calbiochem

440202
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      Formule empirique Nº CAS
      C₁₉H₁₇NO₃154447-36-6

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      440202-10MG
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          10 mg
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          440202-25MG
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          Disponibilité limitée Disponibilité limitée
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              25 mg
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              440202-5MG
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              Disponibilité limitée Disponibilité limitée
              Interrompu(e)
              Disponible en quantités limitées
              Disponibilité à confirmer
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                  5 mg
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                  Description
                  Aperçu A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Promotes the nuclear accumulation of active GSK-3b. Reported to suppress the proliferation of murine embryonic stem cells. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. Shown to bind to the same site as I-BET (Cat. No. 40101050 ~ 10 µM). A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available.
                  Référence 440202
                  Famille de marques Calbiochem®
                  Synonymes 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
                  Références bibliographiques
                  Références bibliographiques Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
                  Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092.
                  Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330.
                  Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
                  Cardone, M.H., et al. 1998. Science 282, 1318.
                  Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
                  Yano, H., et al. 1995. Biochem. J. 312, 145.
                  Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



                  Selected Citations
                  Lee, J., et al. 2009. Cell Stem Cell 5, 76.


                  Informations produit
                  Numéro CAS 154447-36-6
                  ATP concurrente Y
                  Forme Off-white solid
                  Formule de Hill C₁₉H₁₇NO₃
                  Formule chimique C₁₉H₁₇NO₃
                  Molar Mass 307.4
                  Réversible Y
                  Image de la formule structurale
                  Applications
                  Informations biologiques
                  Cible primaire Phosphatidylinositol 3-kinase
                  Cible primaire IC50 1.4 µM against phosphatidylinositol 3-kinase
                  Pureté ≥98% by HPLC
                  Informations physico-chimiques
                  Perméable aux cellules Y
                  Solubilité DMSO or EtOH
                  Dimensions
                  Informations sur les matériaux
                  Informations toxicologiques
                  Informations de sécurité selon le SGH
                  Informations sur la sécurité
                  Notifications sur l'utilisation du produit
                  Informations relatives au stockage et à l'expédition
                  Code Expé Ambient Temperature Only
                  Toxicité Standard Handling
                  Stockage -20°C
                  Protéger de la lumière Protect from light
                  Ne pas congeler No
                  Instructions spéciales Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
                  Informations sur l'emballage
                  Informations sur le transport
                  Information complémentaire
                  Caractéristiques

                  Documentation

                  FDS

                  Langues
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                  Certificats d'analyse

                  TitreNuméro de lot
                  440202

                  Références bibliographiques

                  Aperçu de la référence bibliographique
                  Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
                  Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092.
                  Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330.
                  Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
                  Cardone, M.H., et al. 1998. Science 282, 1318.
                  Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
                  Yano, H., et al. 1995. Biochem. J. 312, 145.
                  Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



                  Selected Citations
                  Lee, J., et al. 2009. Cell Stem Cell 5, 76.


                  Informations techniques

                  Titre
                  JAK/STAT Signaling Research Focus

                  Citations

                  Titre
                • Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092.
                • Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330.
                • Oliveira, J.B., et al. 2007. Procedings of the National Academy of Science 104, 8953.
                • Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.
                • Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.
                • Qian Yang, et al. (2006) TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proceedings of the National Academy of Sciences (USA) 103, 6811-6816.
                • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
                • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
                • Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.
                • Meenalakshmi M. Mariappan, M.M., et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
                • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
                • Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.
                • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
                • Fiche technique

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Révision 28-February-2012 RFH
                  Synonymes 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
                  Description A cell-permeable, potent, reversible, and specific phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor that acts on the ATP-binding site of the enzyme (IC50 = 1.4 µM). Also inhibits nonhomologous DNA end-joining (NHED) in the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activity of EGF receptor kinase, MAP kinase, PKC, PI 4-kinase, S6 kinase, and c-src at 50 µM. Promotes the nuclear accumulation of active GSK-3b. Reported to suppress the proliferation of murine embryonic stem cells. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. Reported to inhibit histamine secretion in RBL-2H3 cells (IC50 = 5 µM).
                  Forme Off-white solid
                  Numéro CAS 154447-36-6
                  Masse molaire 307.4
                  Formule chimique C₁₉H₁₇NO₃
                  Formule structurale
                  Pureté ≥98% by HPLC
                  Solubilité DMSO (20 mg/ml) or Ethanol. Slight warming may be required to achieve complete solubilization.
                  Stockage -20°C
                  Protect from light
                  Do Not Freeze No
                  Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
                  Toxicité Standard Handling
                  Références bibliographiques Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
                  Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092.
                  Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330.
                  Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
                  Cardone, M.H., et al. 1998. Science 282, 1318.
                  Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
                  Yano, H., et al. 1995. Biochem. J. 312, 145.
                  Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



                  Selected Citations
                  Lee, J., et al. 2009. Cell Stem Cell 5, 76.


                  Citation
                • Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092.
                • Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330.
                • Oliveira, J.B., et al. 2007. Procedings of the National Academy of Science 104, 8953.
                • Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.
                • Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.
                • Qian Yang, et al. (2006) TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proceedings of the National Academy of Sciences (USA) 103, 6811-6816.
                • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
                • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
                • Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.
                • Meenalakshmi M. Mariappan, M.M., et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
                • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
                • Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.
                • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.