525185 | Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem

525185
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      Overview

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula CAS #
      C₁₆H₁₆F₃NO₂S 200933-14-8

      Prix & Disponibilité

      RéférenceDisponibilité Conditionnement Qté Prix Quantité
      525185-10MG
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      Disponibilité limitéeDisponibilité limitée
      En stock
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Remaining : Will advise
          Nous vous tiendrons informé

          10 mg
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          Description
          Overview A novel sulfonamide compound that acts as a cell-permeable and specific activator of phospholipase C (PLC). Shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production, and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2, and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase, or PLD.
          Catalogue Number 525185
          Brand Family Calbiochem®
          Synonyms m-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
          References
          References Bae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.
          Product Information
          CAS number 200933-14-8
          ATP Competitive N
          Form Off-white solid
          Hill Formula C₁₆H₁₆F₃NO₂S
          Chemical formula C₁₆H₁₆F₃NO₂S
          Molar Mass 343.4
          Reversible N
          Structure formula Image
          Applications
          Biological Information
          Primary Target Phospholipase C (PLC)
          Purity ≥95% by HPLC
          Physicochemical Information
          Cell permeable Y
          Solubility DMSO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          FDS

          Title

          Material Safety Data Sheet (MSDS)  

          Certificats d'analyse

          TitreNuméro de lot
          525185

          Références bibliographiques

          Aperçu de la référence bibliographique
          Bae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.

          Citations

          Titre
        • Eva Mortier, et al. (2005) Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. The EMBO Journal 24, 2556-2565.
        • Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision 26-August-2008 RFH
          Synonyms m-3M3FBS, 2,4,6-Trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide
          Description A cell-permeable and specific activator of phospholipase C (PLC). Reported to stimulate PLC-mediated intracellular Ca2+ release, inositol phosphate production, and superoxide generation in various cell types. Activates all PLC isotypes (β2, β3, γ1, &gamma2, and δ1) in vitro, but does not exhibit any effect on heterotrimeric G proteins, PI 3-kinase, or phospholipase D.
          Form Off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number 200933-14-8
          Molar mass 343.4
          Chemical formula C₁₆H₁₆F₃NO₂S
          Structure formula
          Purity ≥95% by HPLC
          Solubility DMSO (7 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Carcinogenic / Teratogenic
          References Bae, Y.S., et al. 2003. Mol. Pharmacol. 63, 1043.
          Citation
        • Eva Mortier, et al. (2005) Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. The EMBO Journal 24, 2556-2565.